Christopher Kepley

There are 11 included publications by Christopher Kepley :

TitleDateViewsBrief Description
Application of Fullerenes in Nanomedicine: an Update 2013 1452 Fullerenes are carbon spheres presently being pursued globally for a wide range of applications in nanomedicine. These molecules have unique electronic properties that make them attractive candidates for diagnostic, therapeutic and theranostic applic...
C5a Receptor Enables Participation of Mast Cells in Immune Complex Arthritis Independently of Fc? Receptor Modulation 2010 430 Objective: Mast cells are tissue-resident immune sentinels that are implicated in the pathogenesis of inflammatory joint disease. The aim of this study was to test our hypothesis that complement fragments could be key activators of synovial mast cell...
Effects of Novel Nanomaterials on Allergic Mediator Release from Human Mast Cells and Basophils through Non-Ige Mediated Pathways 2012 641 Mast cells (MC) and peripheral blood basophils (PBB) are well known for their role in the allergic response mediated through high affinity IgE receptors (FceRI). However, these cells can also be stimulated by other non-allergic secretagogues to relea...
Epoxyeicosatrienoic acids are involved in the C70 fullerene derivative–induced control of allergic asthma 2012 590 Background: Fullerenes are molecules being investigated for a wide range of therapeutic applications. We have shown previously that certain fullerene derivatives (FDs) inhibit mast cell (MC) function in vitro, and here we examine their in vivo therap...
Fullerene Antioxidants Decrease Organophosphate-induced Acetylcholinesterase Inhibition in vitro 2011 759 Although organophosphate (OP)-induced acetylcholinesterase (AChE) inhibition is the critical mechanism causing toxicities that follow exposure, other biochemical events, including oxidative stress, have been reported to contribute to OP toxicity. Ful...
Fullerene Nanomaterials Inhibit Phorbol Myristate Acetate-induced Inflammation 2009 536 Inflammation is a natural biological response that occurs when vascular tissues are subjected to harmful stimuli. This process may be beneficial to the host during wound healing and infections but can be detrimental if left unchecked. Oxidative stres...
Functionalization of Gadolinium Metallofullerenes for Detecting Atherosclerotic Plaque Lesions by Cardiovascular Magnetic Resonance 2013 518 Background: The hallmark of atherosclerosis is the accumulation of plaque in vessel walls. This process is initiated when monocytic cells differentiate into macrophage foam cells under conditions with high levels of atherogenic lipoproteins. Vulnerab...
IL-33/ST2 axis promotes mast cell survival via BCLXL 2014 824 Mast cells (MC) are potent innate immune cells that accumulate in chronically inflamed tissues. MC express the IL-33 receptor IL-1 receptor-related protein ST2 at high level, and this IL-1 family cytokine both activates MC directly and primes them to...
In Vitro Desensitization of Human Skin Mast Cells 2012 637 Desensitization is a clinical procedure whereby incremental doses of a drug are administered over several hours to a sensitive patient until a therapeutic dose and clinical tolerance are achieved. Clinical tolerance may occur in part by attenuating t...
A New Class of Human Mast Cell and Peripheral Blood Basophil Stabilizers that Differentially Control Allergic Mediator Release 2010 733 Treatments for allergic disease block the effects of mediators released from activated mast cells and blood basophils. A panel of fullerene derivatives was synthesized and tested for their ability to preempt the release of allergic mediators in vitro...
A Potential New Target for Asthma Therapy: A Disintegrin and Metalloprotease 10 (ADAM10) Involvement in Murine Experimental Asthma 2011 354 Background: Elevated levels of CD23, a natural regulator of IgE production, have been shown to decrease the signs of lung inflammation in mice. The aim of this study was to study the involvement of ADAM10, the primary CD23 sheddase, in experimental ...