Polyhydroxylated C60 fullerene (fullerenol) attenuates neutrophilic lung inflammation in mice

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Christopher Kepley, Associate Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/

Abstract: Inflammation is crucial to eliminate pathogens and promote repair of injured tissue. However, excessive or persistent inflammation can contribute to tissue injury and the pathogenesis and exacerbation of diseases, including inflammatory lung diseases, such as chronic obstructive pulmonary disease [1] and silicosis [2]. Neutrophilic inflammation is an important aspect of chronic obstructive pulmonary disease [1, 3, 4] and silicosis [2, 5]. Thus, in human beings, a relationship between exposure to respirable silica in coal mine dust and pulmonary inflammation is seen, resulting in an elevated neutrophil count in bronchoalveolar lavage fluid (BALF) [6]. Exposure to silica can cause silicosis, where the severe inflammation in the lung appears to be an initiating step in the development of the disease [7]. The quartz particles can in itself generate reactive oxygen species (ROS), but additional inflammatory injuries appear to be a result of the influx of inflammatory cells [2]. The cell-generated ROS and nitric oxide radicals are hallmarks of the toxicity of the quartz particles [8, 9], and quartz-induced inflammation is characterised by, for example, neutrophilic inflammation in rodents [10]. The importance of neutrophils in the development of inflammatory lung diseases has been reported in rodents, where exposure to quartz resulted in induced influx of neutrophils [2, 4, 11-15]. Furthermore, it was shown that treatment with anti-macrophage inflammatory protein 2 (MIP-2) antiserum prior to quartz exposure attenuated neutrophil influx [16], suggesting that MIP-2 can play an important role in quartz-induced neutrophilic lung inflammation.

Additional Information

Pharmacology and Toxicology 2008; 103(4):386-8
Language: English
Date: 2008
inflammatory lung disease, pulmonary inflammation, neutrophils, fullerenol

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