Syk deficiency in human non-releaser lung mast cells
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Christopher Kepley, Associate Professor (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: Human lung mast cells, like peripheral blood basophils, can have a non-releaser phenotype characterized by a failure to respond to FceRI-IgE-mediated stimulation [1]. Previous studies on human basophils demonstrated that approximately 10–15% of donors fail to release histamine in response to FceRI crosslinking [2], [3], [4], [5] and that depressed protein levels of the tyrosine kinase Syk correlated with this non-releaser status [6], [7]. Here we present evidence for diminished Syk protein in a second preparation of lung mast cells with a non-releasing phenotype.
Syk deficiency in human non-releaser lung mast cells
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Created on 8/13/2019
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Additional Information
- Publication
- Clinical Immunology 2007; 125(1):112-5.
- Language: English
- Date: 2007
- Keywords
- letter to the editor, lung mast cells, non-releaser phenotype, Syk, IgE