Dasyscyphins F and G, new drimane meroterpenoids from a Fitzroyomyces species

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Mario Augustinovic (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/
Nicholas Oberlies

Abstract: As part of an ongoing investigation into the pharmaceutical potential of filamentous fungi, two new drimane meroterpenoids were discovered, which showed moderate cytotoxic activity across three cancer cell lines (MDA-MB-435, MDA-MB-231, OVCAR3). Compounds were isolated from a solid fermentation of Fitzroyomyces sp. (fungal strain MSX62440) and their structures were elucidated through NMR and HRESIMS data analysis. Absolute configuration was assigned through a combination of chiroptic and spectroscopic techniques in conjunction with predicted ECD calculations. Dasyscyphin G, previously published as a synthetic precursor to known compound dasyscyphin B, was also isolated as a natural product. Two compounds also showed activity against B. anthracis. Structure revision of dasyscyphin C was also performed based on ECD and NMR calculations.

Additional Information

Language: English
Date: 2020
Chemistry, Filamentous fungi, Cancer cell lines
Filamentous fungi
Pharmaceutical chemistry

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