Oberlies, Nicholas

uncg

There are 17 item/s.

TitleDateViewsBrief Description
Use of adsorbent resins in fermentations of bacteria obtained from the red soils of the Kingdom of Jordan and the isolation and structure elucidation of cytotoxic xanthones from an unidentified fungus 2012 3070 Part I: Adsorbent resins are used in industrial fermentations to help boost the production of antibiotics. The resins used here were utilized to help speed the drug discovery process by eliminating the time-consuming step of freeze-drying the ferment...
Applications of mass spectrometry surface sampling techniques towards natural products research 2016 1067 Since the pharmaceutical industry has experienced a decline in output over the past decade, natural products research has regained interest. The complexity and molecular diversity seen in nature remains unmatched, even against combinatorial chemistry...
Isolation of fungal secondary metabolites: leporin B, benzoisoquinoline and related compounds 2017 709 Natural products have proven to be a good source of anticancer drugs since the 1940’s. In fact, they have influenced the creation of 65% of all 246 anticancer drugs since that time. Fungi in particular provide an almost untapped source of compounds w...
Growth media studies approach to enhance production of the bioactive fungal metabolite viridicatumtoxin A 2018 257 Viridicatumtoxin A is a unique tetracycline-like aromatic polyketide first isolated as a mycotoxin from Penicillium viridicatum in 1973. Along with its 5-oxo derivative, viridicatumtoxin B, discovered in 2008 from the liquid fermentation cultures of ...
Discovering new structural diversity from unexplored fungi 2014 2856 Discovery of anticancer drugs with high efficacy coupled with action at novel target sites is necessary to combat cancer. As part of a multidisciplinary project to identify anticancer leads from diverse natural product resources, our group has been s...
Investigating the diversity of secondary metabolites from filamentous fungi 2017 216 Natural products continue to be a fertile source of leads for drug discovery, as a large extent of the world’s biodiversity has been untapped for their chemical diversity and biological activity. With the continuing need for new drug leads due to the...
Isolation of novel naphthoquinones from fungal strain MSX53507, Cladorrhinum sp. 2019 24 This study was conducted as part of an ongoing collaborative project to investigate the chemical diversity of fungi in search of new anticancer drug leads. Fungi have shown to be prolific producers of dynamic secondary metabolites, which exhibit a va...
Steps in the journey to advance the study of nature’s chemistry 2019 25 “A journey of a thousand miles begins with a single step” is a saying from the philosopher of Laozi, the founder of Taosim, and Taoism believes in living in harmony with the universe or nature itself. This seems particularly appropriate to describe t...
Fingolimod (Gilenya; FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite and the creation of a natural products pure compound database and organized storage system 2012 13285 Fingolimod (Gilenya; FTY720), a synthetic compound based on the fungal secondary metabolite, myriocin (ISP-I), is a potent immunosuppressant that was approved in September 2010 by the U.S. FDA as a new treatment for multiple sclerosis (MS). Fingolimo...
Milk thistle flavonolignans: biomimetic synthesis, synthesis of analogues and biological evaluation of synthetic products 2013 11975 7-O-methylflavonolignans from milk thistle were synthesized by first isolating the seven primary components of silymarin and individually methylating them. Optimization of conditions allowed for each of these seven compounds to be selectively methyla...
Bioactive natural products: isolation of fungal secondary metabolites and applications of green chemistry 2013 4887 Natural products have played a significant role in the drug discovery especially in the area of cancer. Over the period of 1940-2010, 50% of the small molecules introduced as anticancer agents were either natural products or directly derived therefro...
The pursuit of chemical diversity in fungi 2020 94 Fungi are ever changing their secondary metabolites profile in order to adapt to their environment. Previously characterized fungal cultures were re-analyzed with the intention of re-isolating scaled up quantities of metabolites of interest. However,...
Quantitative analysis of grapefruit constituents involved in diet-drug interactions and modification of the microbial metabolome 2014 1096 The term "natural product" refers to secondary metabolites produced by living organisms, and therefore encompasses a number of research concentrations ranging from traditional medicines to microbial lead compounds to the impacts of diet on human heal...
Investigation into qNMR for use in natural products research 2016 188 Natural products research constantly has to deal with problems of analysis. Therefore, orthogonal techniques are extremely valuable when analyzing complex mixtures that are often seen in fungal extracts. Analysis of results of fungal fermentation exp...
Dasyscyphins F and G, new drimane meroterpenoids from a Fitzroyomyces species 2020 2 As part of an ongoing investigation into the pharmaceutical potential of filamentous fungi, two new drimane meroterpenoids were discovered, which showed moderate cytotoxic activity across three cancer cell lines (MDA-MB-435, MDA-MB-231, OVCAR3). Comp...
Precursor directed biosynthesis for the discovery of ‘non-natural’ natural products in fungi 2020 64 Verticillins are a class of dimeric epipolythiodioxopiperazine alkaloids that are known to have IC50 values of 10 nM or less in various human cancer cell lines This biological activity makes them potential candidates in the search of new anticancer d...
Studies on the genotype, phenotype, and co-cultures of Aspergillus section Fumigati and the development of new techniques to enhance structure elucidation of fungal metabolites 2021 3 Fungi are pathogenic to plants, humans, and animals, and secondary metabolites produced by fungi are implicated in these interactions. As part of an interdisciplinary project to identify the chemical and genomic differences between pathogenic and non...