Oberlies, Nicholas

uncg

There are 13 item/s.

TitleDateViewsBrief Description
Use of adsorbent resins in fermentations of bacteria obtained from the red soils of the Kingdom of Jordan and the isolation and structure elucidation of cytotoxic xanthones from an unidentified fungus 2012 2933 Part I: Adsorbent resins are used in industrial fermentations to help boost the production of antibiotics. The resins used here were utilized to help speed the drug discovery process by eliminating the time-consuming step of freeze-drying the ferment...
Fingolimod (Gilenya; FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite and the creation of a natural products pure compound database and organized storage system 2012 13086 Fingolimod (Gilenya; FTY720), a synthetic compound based on the fungal secondary metabolite, myriocin (ISP-I), is a potent immunosuppressant that was approved in September 2010 by the U.S. FDA as a new treatment for multiple sclerosis (MS). Fingolimo...
Milk thistle flavonolignans: biomimetic synthesis, synthesis of analogues and biological evaluation of synthetic products 2013 11825 7-O-methylflavonolignans from milk thistle were synthesized by first isolating the seven primary components of silymarin and individually methylating them. Optimization of conditions allowed for each of these seven compounds to be selectively methyla...
Bioactive natural products: isolation of fungal secondary metabolites and applications of green chemistry 2013 4438 Natural products have played a significant role in the drug discovery especially in the area of cancer. Over the period of 1940-2010, 50% of the small molecules introduced as anticancer agents were either natural products or directly derived therefro...
Discovering new structural diversity from unexplored fungi 2014 2725 Discovery of anticancer drugs with high efficacy coupled with action at novel target sites is necessary to combat cancer. As part of a multidisciplinary project to identify anticancer leads from diverse natural product resources, our group has been s...
Quantitative analysis of grapefruit constituents involved in diet-drug interactions and modification of the microbial metabolome 2014 1013 The term "natural product" refers to secondary metabolites produced by living organisms, and therefore encompasses a number of research concentrations ranging from traditional medicines to microbial lead compounds to the impacts of diet on human heal...
Investigation into qNMR for use in natural products research 2016 138 Natural products research constantly has to deal with problems of analysis. Therefore, orthogonal techniques are extremely valuable when analyzing complex mixtures that are often seen in fungal extracts. Analysis of results of fungal fermentation exp...
Applications of mass spectrometry surface sampling techniques towards natural products research 2016 989 Since the pharmaceutical industry has experienced a decline in output over the past decade, natural products research has regained interest. The complexity and molecular diversity seen in nature remains unmatched, even against combinatorial chemistry...
Isolation of fungal secondary metabolites: leporin B, benzoisoquinoline and related compounds 2017 645 Natural products have proven to be a good source of anticancer drugs since the 1940’s. In fact, they have influenced the creation of 65% of all 246 anticancer drugs since that time. Fungi in particular provide an almost untapped source of compounds w...
Investigating the diversity of secondary metabolites from filamentous fungi 2017 103 Natural products continue to be a fertile source of leads for drug discovery, as a large extent of the world’s biodiversity has been untapped for their chemical diversity and biological activity. With the continuing need for new drug leads due to the...
Growth media studies approach to enhance production of the bioactive fungal metabolite viridicatumtoxin A 2018 217 Viridicatumtoxin A is a unique tetracycline-like aromatic polyketide first isolated as a mycotoxin from Penicillium viridicatum in 1973. Along with its 5-oxo derivative, viridicatumtoxin B, discovered in 2008 from the liquid fermentation cultures of ...
Precursor directed biosynthesis for the discovery of ‘non-natural’ natural products in fungi 2020 19 Verticillins are a class of dimeric epipolythiodioxopiperazine alkaloids that are known to have IC50 values of 10 nM or less in various human cancer cell lines This biological activity makes them potential candidates in the search of new anticancer d...
The pursuit of chemical diversity in fungi 2020 15 Fungi are ever changing their secondary metabolites profile in order to adapt to their environment. Previously characterized fungal cultures were re-analyzed with the intention of re-isolating scaled up quantities of metabolites of interest. However,...