Coumarins, dihydroisocoumarins, a dibenzo-a-pyrone, a meroterpenoid, and a merodrimane from Talaromyces amestolkiae
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Mario Figueroa Saldivar, Adjunct Faculty (Creator)
- Nicholas Oberlies, Patricia A. Sullivan Distinguished Professor of Chemistry (Creator)
- Huzefa A. Raja, Research Scientist (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: Chemical investigation of an organic extract of a fungus isolated from submerged wood collected from fresh water (strain G173), identified as a Talaromyces amestolkiae (Eurotiales; Trichocomaceae), led to the isolation of three coumarins, three dihydroisocoumarins, a dibenzo-a-pyrone, a meroterpenoid, and a merodrimane. Three of the isolated compounds, namely 7-chloropestalasin A (3), 4-hydroxyaspergillumarin (6), and ent-thailandolide B (9) were new. The structures were elucidated using a combination of spectroscopic and spectrometric techniques. The absolute configurations of 2, 3, 5, and 6 were established via a modified Mosher’s ester method, whereas for 9 a combination of TDDFT ECD and ORD calculations were employed. Compounds 1–9 were evaluated for antimicrobial activity against a group of bacteria and fungi. [The original abstract for this article contains (characters/images) that cannot be displayed here. Please click on the link below to read the full abstract and article.]
Coumarins, dihydroisocoumarins, a dibenzo-a-pyrone, a meroterpenoid, and a merodrimane from Talaromyces amestolkiae
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Created on 5/10/2021
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Additional Information
- Publication
- Tetrahedron Letters. 2021, Article number 153067. DOI: 10.1016/j.tetlet.2021.153067
- Language: English
- Date: 2021
- Keywords
- Freshwater Fungi, Coumarins, Dihydroisocoumarins, Dibenzo-a-pyrones, Meroterpenoids, Merodrimanes