|Chemical Composition and Anti-proliferative Activity of Several Medicinal Plants
||Plants are valuable sources of medicinal compounds and their use for healing is well known from ancient times. Natural drugs obtained from plants represent about 25% of the prescription drug market in the United States. Plants have a long history of ...
|Goldenseal: a case study on LC-MS profiling to identify synergists
||The purported activity of goldenseal, Hydrastis canadensis L., against a plethora of disease states is largely attributed to the presence of the benzoisoquinoline alkaloid berberine in the plant. However, goldenseal crude extracts showed better inhib...
|Identification, quantification and investigation of anti-inflammatory effects of Echinacea purpurea constituents
||Echinacea is among the top selling botanical medicines in the United States. Clinical trials have yielded contradictory reports on the efficacy of Echinacea preparations for treatment of colds, influenza, and inflammation, perhaps due to inconsistenc...
|Analytical development for analysis of American ginseng and multiple agriculturual chemicals from soil
||Ginseng has been used for thousands of years as an herbal remedy for many common ailments. Ginsenosides from ginseng have shown a wide range of biological effects, including antioxidant and anti-cancer properties. The goal of this project was to deve...
|Inhibiting antimicrobial resistance in Staphylococcus aureus using natural products
||Since the treatment of infections with antibiotics, Staphylococcus aureus has developed resistance to antimicrobial agents. Methicillin-resistant S aureus (MRSA) contributes significantly to the healthcare burden of both hospital and community infect...
|Dual sources of antimicrobial activity of Anemopsis californica : plant and endophytic fungi
||Anemopsis californica is a plant native to the southwestern United States and northern Mexico that has been used by many Native American tribes to alleviate pain and inflammation and to treat infection. Limited research has examined the chemical comp...
|Studies on bacterial Efflux pump inhibitors in land plants
||The research presented in this dissertation deals with the phenomena of bacterial efflux pump inhibition by natural products and plant extracts. Bacterial efflux pumps are active transport proteins, primarily deriving their energy source from the pro...
|Exploration of quorum sensing inhibition in gram positive bacterial pathogens using mass spectrometry
||Antibiotics have been used as the primary treatment for bacterial infections since the 1940’s. Unfortunately, the use and misuse of antibiotics has led to the proliferation of antibiotic-resistant bacteria and resulted in the loss of antibiotic effic...
|Antimicrobial compounds from endophytic fungi of goldenseal (Hydrastis canadensis)
||With this study, we explored the potential role of fungal endophytes in the antimicrobial activity of the medicinal plant goldenseal, Hydrastis canadensis L. (Ranunculaceae). A total of 23 fungal cultures were obtained from surface-sterilized samples...