Alkynes and Azides: Not Just for Click Reactions.
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Mitchell Croatt, Assistant Professor (Creator)
- Maria Elena Meza-Avina, Research Scientist (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: We recently reported two unexplored reactivities of alkynes and azides. The first method reacts nucleophilic alkynes and electrophilic azides to synthesize sulfonyl-substituted 1,5-disubstituted-1,2,3-triazoles. The second method reacts electrophilic alkynes with nucleophilic azides to form alkynyl-azides that immediately extrude dinitrogen to form cyanocarbenes which were trapped by O-H insertion, sulfoxide complexation, and cyclopropanation. The design and discovery of these reactions, along with key observations, is discussed herein.
Alkynes and Azides: Not Just for Click Reactions.
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Created on 3/20/2013
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Additional Information
- Publication
- Language: English
- Date: 2012
- Keywords
- azides, alkynes, carbenes, umpolung, heterocycles, chemistry, biochemistry