Metabolic profiling reveals therapeutic effects of Herba Cistanches in an animal model of hydrocortisone-induced 'kidney-deficiency syndrome'
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Wei Jia, Professor and Co-Director of the UNCG Center for Research Excellence in Bioactive Food Components (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: Background: Herba Cistanches (Roucongrong) is effective in treating Shenxu Zheng ('kidneydeficiency syndrome'). However, the mechanisms and systemic metabolic responses to the herbal intervention are unclear.
Methods: Using GC-MS-based metabolic profiling, we investigated the metabolic responses to Herba Cistanches intervention in a rat model of the hydrocortisone-induced 'kidney-deficiency syndrome'.
Results: The metabolic profiles of the rats after hydrocortisone injection deviated from the predose metabolic state at different time points, ranging from day 1 to day 10, whereas the metabolic profiles of the rats treated with both hydrocortisone and water extract of Herba Cistanches returned to the pre-dose state on day 10.
Conclusion: The intervention of Herba Cistanches caused a systemic recovery from the hydrocortisone-induced metabolic perturbation in rats. This study also demonstrates that metabolic profiling is useful in studying therapeutic mechanisms of herbal medicines.
Metabolic profiling reveals therapeutic effects of Herba Cistanches in an animal model of hydrocortisone-induced 'kidney-deficiency syndrome'
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Created on 6/28/2012
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Additional Information
- Publication
- Chinese Medicine, 3:3
- Language: English
- Date: 2008
- Keywords
- Herba Cistanches, kidney-deficiency syndrome, metabolic profiling, hydrocortisone, therapy