Urinary Metabolomics as a Potentially Novel Diagnostic and Stratification Tool for Knee Osteoarthritis
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Wei Jia, Professor and Co-Director of the UNCG Center for Research Excellence in Bioactive Food Components (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: Metabolomics has been used as a tool in disease diagnosis and phenotype prediction. A urinary metabolomic study based on GC–MS in combination with multivariate statistics was used here to classify between knee osteoarthritis (OA) and healthy controls. OPLS-DA of the spectral data showed distinct metabolic profile variations between OA patients and healthy controls and between two OA phenotypes. Differential metabolites reveal up-regulated TCA cycle associated with OA and histamine metabolism disorders accompanied with knee effusion symptoms. This metabolomic method is potentially applicable as a novel strategy for OA diagnosis and patient stratification.
Urinary Metabolomics as a Potentially Novel Diagnostic and Stratification Tool for Knee Osteoarthritis
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Created on 6/25/2012
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Additional Information
- Publication
- Metabolomics, 6(1), 109-118
- Language: English
- Date: 2010
- Keywords
- metabolomics, osteoarthritis, phenotype, stratification, biomarker, histamine