The Ecdysone Receptor Puzzle
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Vincent C. Henrich, Professor (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: The present article reviews some recent findings on the functional ecdysone† receptor which is a heterodimer of two proteins: ecdysone receptor (EcR) and Ultraspiracle (USP). Emphasis is given to some unique aspects of this receptor, in particular to its dimerization, binding to DNA, and transactivation capabilities. The effects of ligands (ecdysone, juvenile hormone) on these functions are discussed. In addition, perspectives on future work on this receptor are outlined, which are shaped by recent progress in the nuclear receptor field in general. This preview part of the present article concerns mainly the 3-D structure of receptor domains, the formation of large supramolecular receptor complexes, their influence on chromatin remodelling, receptor phosphorylation, as well as inter- and intramolecular cross-talks of receptor domains.
The Ecdysone Receptor Puzzle
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Created on 6/23/2011
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Additional Information
- Publication
- Archives of Insect Biochemistry and Physiology
- Language: English
- Date: 1999
- Keywords
- ecdysone receptor, Ultraspiracle, receptor dim erization, juvenile hormone, transactivation