A developmental time scale for postnatal changes in brain and behavior of B6D2F₂ mice.

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)

Douglas Wahlsten, Visiting Professor (Creator)

Institution

The University of North Carolina at Greensboro (UNCG )

Web Site: http://library.uncg.edu/

Abstract: A time scale for postnatal development was devised by testing separate litters of mice on 10 consecutive days (27.0-36.0 gestation days, or 8.5-17.5 days after birth) for behavioral abilities, body weight, brain weight, myelination of 80 fiber tracts and thickness of the external granular layer of the cerebellum (EGL). Although body and brain weights showed large variance within a litter or unstable changes across days, the other measures of brain and behavior underwent precise, monotonic changes with age. A time scale employing measures of reflexes, myelination and EGL thickness was presented which could be used to predict accurately the developmental age of a mouse. Detailed data were presented which revealed a general caudal—rostral gradient for brain maturation and a rostral—caudal trend for reflex ontogeny.

A developmental time scale for postnatal changes in brain and behavior of B6D2F₂ mice.
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Created on 6/7/2011
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Additional Information

Publication

Brain Research, 1974, 72, 251-264.

Language: English

Date: 1974

Keywords

Mice, Development, Baseline, Normal, Control

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