Core-shell - Cobalt oxide @ carbon nanodot hybrid nanoparticles : evaluation for photocatalytic and cancer theranostic applications
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Anitha Jayapalan (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
- Advisor
- Jianjun Wei
Abstract: Metal oxide carbon-based nanocomposites have gained tremendous consideration in recent years due to the porous metal oxides with carbon structural and morphological tunability for their use in wide areas of research, such as catalysis, energy storage, and theranostic applications. These types of hybrid nanocomposites are advantageous as the metal oxides have a high storage capacity for catalytic applications, and their toxicity could be considerably reduced by carbon shell architectures to improve bioavailability. Cobalt oxide nanoparticles (Co3O4 NPs) and carbon nanodots (CNDs) were chosen for this research to construct a hybrid core-shell structure to achieve multifunctionalities by synergizing the spinel nature of the Co3O4 NPs with its mixed valence state and the porous CNDs. Specifically, this dissertation work is focused on the evaluation of the synergistic properties of Co3O4@CND hybrid NPs, for the photocatalytic activity in the photodegradation of dye molecules (Chapter two), energy storage as supercapacitor materials (Chapter three), and the delivery of small drugs to cancer cells for theranostic study (Chapter four). In chapter one, a comprehensive review of the multifunctional hybrid core-shell NPs with Co3O4 NPs and CNDs with a brief literature knowledge on their physicochemical, optoelectronic, and biological properties and their various applications was provided. In Chapter two, the photocatalytic activity of the Co3O4@CND hybrid NPs was investigated by evaluating the photodegradation of organic dye upon visible and UV lights, respectively. The results indicated that the Co3O4@CND hybrid NPs had higher efficiency and kinetics in dye degradation than Co3O4 NPs or CNDs. This high efficiency and kinetics were explained by the heterojunction interfacial surface between the core Co3O4 NPs and shell CNDs, which improved the electron-hole pair separation and migration for the photocatalytic reactions. In chapter three, the Co3O4@CND hybrid NPs used in a supercapacitor electrode and evaluated the energy storage by electrochemical means and compared to Co3O4 NPs or CNDs. The cyclic voltammetry experiments were performed to evaluate the capacitance performance of the Co3O4@CNDs hybrid NPs as a supercapacitor with different binder solvents, including nafion, polyvinyl difluoridine (PVDF), and polytetrafluoroethylene and activated carbons. The findings of this thrust are that the capacitance with the PVDF binders and activated carbons of the Co3O4@CNDs hybrid NPs showed better energy storage than other binders used. In chapter 4, the use of Co3O4@CND hybrid NPs for imaging and specific targeting of cancer cells was investigated. The multifunctional biological applications of the hybrid NPs in cellular imaging, antioxidant effect in cells, and anticancer activity with or without conjugating small drug molecules, including polymers (polyethylene glycol) and ligands (folic acid, heparin, and transferrin) were evaluated, and proven. Improved anticancer efficacy and bioavailability of Co3O4@CNDs were achieved through a receptor-ligand activation mechanism for specific cancer cell targeting. Co3O4@CND hybrid NPs-transferrin-DOX ligand complex demonstrated specific anticancer activity of almost 50% for lung cancer cells without harming normal human endothelial cells. The overall findings of this dissertation work presented advanced knowledge associated with the structural properties of core-shell Co3O4@CND hybrid NPs, superior performance in photocatalysis, energy storage, and cancer theranostic effects, and a fundamental understanding of their reactions. [This abstract may have been edited to remove characters that will not display in this system. Please see the PDF for the full abstract.]
Core-shell - Cobalt oxide @ carbon nanodot hybrid nanoparticles : evaluation for photocatalytic and cancer theranostic applications
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Created on 5/1/2023
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Additional Information
- Publication
- Dissertation
- Language: English
- Date: 2023
- Keywords
- Anticancer agent, Bioimaging, Cancer theranostics, Core-Shell Nanoparticles, Hybrid Nanoparticles, Photocatalytic Activity
- Subjects
- Antineoplastic agents
- Nanocomposites (Materials)
- Nanomedicine