Growth media studies approach to enhance production of the bioactive fungal metabolite viridicatumtoxin A

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Olalekan Saheed Oyekunle (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site:
Nicholas Oberlies

Abstract: Viridicatumtoxin A is a unique tetracycline-like aromatic polyketide first isolated as a mycotoxin from Penicillium viridicatum in 1973. Along with its 5-oxo derivative, viridicatumtoxin B, discovered in 2008 from the liquid fermentation cultures of another Penicillium sp. (strain FR11) has exhibited cytotoxicity against the NCI-H460 human lung carcinoma cell line, KB3-1 human cervix carcinoma cell line, and SW620 human colon carcinoma cell line with reported IC50 values of 1.0 µM, 2.5 µM and 1.0 µM respectively. Based on the scarcity and the more bioactive properties of viridicatumtoxin B, Nicolaou and coworkers in 2013 achieved the total synthesis of viridicatumtoxin B; albeit through a lengthy protocol which would not be scalable. In this context, and as part of our ongoing research centered on the optimization of drug leads for the treatment of cancer, my project is focused on the enhanced production of viridicatumtoxin A from fungal cultures which would provide materials for synthesis of more bioactive analogues.

Additional Information

Language: English
Date: 2018
Bioactive fungal metabolite, Cytotoxic fungal extracts, Fungal domestication, Growth media, Natural Products, Viridicatumtoxin A
Antineoplastic antibiotics
Plant bioactive compounds
Fungal metabolites

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