|Regulation of Myosin II Isoform Localization and Activation during Insulin Stimulated Glucose Uptake in 3T3-L1 Adipocytes.
||Insulin stimulated glucose uptake is a critical component of glucose homeostasis. The studies presented here show that myosin IIA is actively recruited to the plasma membrane upon insulin stimulation. I also show that inhibiting the interaction of my...
|The Role of Myosin II in GLUT4 Activity and Membrane Fusion during Insulin-Stimulated Glucose Uptake in 3T3-L1 Adipocytes.
||Insulin-stimulated glucose uptake is a vital physiological process, which requires the translocation and fusion of insulin sensitive glucose transporter (GLUT4) vesicles from intracellular pools to the plasma membrane. Previous studies have implicate...
|Characterization of the role of myosin II during insulin-stimulated glucose uptake in 3T3-L1 adipocytes
||Insulin-stimulated glucose uptake requires the activation of the nonmuscle motor protein myosin II. Our previous studies using pharmacological inhibitors suggest that insulin signaling results in the phosphorylation of myosin IIA during insulin-stimu...
|Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes
||Insulin stimulated glucose uptake in adipocytes requires the co-localization of myosin IIA (myoIIA) and glucose transporter 4 (GLUT4) at the plasma membrane. Our previous studies have shown that glucose uptake decreases dramatically if either GLUT4 o...
|Targeting multiple proliferation pathways as a novel breast cancer treatment
||Estrogen receptor alpha positive (ERa+) breast cancer cells proliferate and survive by utilizing multiple pathways. Thus, combination chemotherapies targeting multiple pathways may be used to decrease ERa+ breast cancer cell density. Tamoxifen (Tam),...
|The role of reactive oxygen species in insulin resistance
||Insulin resistance and type II diabetes mellitus are major public health issues in the U.S.; more specifically insulin resistance is strongly correlated with obesity. Multiple factors influence insulin resistance such as hyperglycemic conditions and ...
|Analysis of molecular target(s) of naringenin in MCF-7 breast cancer cells
||Estrogen receptor (ER) antagonists such as tamoxifen have been used successfully to treat ER+ breast cancers for more than 30 years. Tamoxifen targets the ER and blocks the binding of estrogen thus preventing up-regulation of estrogen responsive gene...