| Title | Date | Views | Brief Description |
|---|
| Studies of environmental pollutant acrolein-induced endothelial dysfunction: the role of glutathione and nf-kappab |
2015 |
619 |
Environmental pollutant exposure has gained considerable attention as a potential risk factor contributing towards cardiovascular diseases (CVDs). Acrolein is a highly reactive electrophilic aldehyde known for its ubiquitous presence in the atmospher... |
| Doxorubicin-induced cytotoxicity in rat myocardial H9c2 cells: the roles of reactive oxygen species and redox balance |
2017 |
1107 |
Doxorubicin (Dox) is one of the most potent anti-neoplastic agents approved by the Food and Drug Administration. Its efficacy, however, is limited due to its well-documented cardiotoxic side effect. Since the first observation of this dosage-dependen... |
| Carbon nanodot cellular uptake and modulation of Tumor necrosis factor-alpha-induced endothelial dysfunction |
2018 |
291 |
In the past forty years, we have advanced our understanding of cardiovascular pathology through epidemiological and molecular studies. Atherosclerosis is one of the main cardiovascular diseases, which is also an underlying cause of more severe cardio... |
| Carbon nanodots in endothelial cells and C57BL/6 mice: a study of toxicity and anti-inflammatory effect |
2018 |
397 |
The advancement of therapy for cardiovascular disease (CVD) is paramount to public health, as it is the leading global cause of mortality [1]. Nanomedicine provides new opportunities in the ongoing efforts to reduce the economic and healthcare conseq... |
| Investigation of endothelial cell injury and dysfunction induced by air pollutant benzo-a-pyrene-1,6-quinone: implications in chemical atherogenesis |
2018 |
197 |
Cardiovascular diseases (CVD) are the leading cause of death for men and women in the USA, and growing evidence has led to an increase in concern about the detrimental effect of airborne particulate matter (PM) on health and its relation to the devel... |
| Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity |
2013 |
700 |
Evidence suggests oxidative and electrophilic stress as a major factor contributing to the neuronal cell death in neurodegenerative disorders, especially Parkinson's disease (PD). Early depletion in the levels of thiol antioxidant glutathione (GSH), ... |
| Upregulation of ROS detoxification genes by triterpenoid CDDO-Im in macrophages: protection against lipopolysaccharide-induced inflammatory injury |
2019 |
266 |
Dysregulated response by the body towards an infection leads to tissue and organ damage is known as sepsis. Currently, approximately 18 million people worldwide are affected by this deadly disease annually. Septic shock, a severe form of sepsis, cont... |
| Cellular Uptake of Carbon Nanodots in THP-1 Human Monocytes |
2019 |
379 |
Cardiovascular disease (CVD) is the leading cause of death worldwide. Many types of treatment options are currently available but include side effects that inhibit quality living for many people. Carbon nanodots are novel carbon nanoparticles with si... |
| Roles of endothelial dysfunction and injury in mercury-induced cardiotoxicity |
2019 |
278 |
Cardiovascular disease (CVD) is the leading global cause of mortality and morbidity and presents a significant economic impact in the form of healthcare costs. The development of cardiovascular disease has many facets ranging from unhealthy lifestyle... |
| Carbon nanodot uptake and their effects on macrophages upon challenge with oxidized LDL and TNF-alpha |
2019 |
246 |
Atherosclerosis, a leading cause of cardiovascular disease worldwide, represents a global concern because of its large economic and public welfare burden. Macrophages play important physiological and pathological roles in the development of atheroscl... |
| A study of the effect of carbon nanodots on proinflammatory cytokine TNF-a induced endothelial dysfunction. |
2020 |
127 |
Cardiovascular disease (CVD) has become an increasingly important topic in the field of medical research due to the steadily increasing rates of mortality caused by this disease [1]. With recent advancements in nanotechnology, a push for new, novel t... |
| Modulation of macrophage polarization by carbon nanodots |
2020 |
121 |
Atherosclerosis represents an ever-present global concern, as it is a leading cause of cardiovascular disease, and an immense public welfare issue. Macrophages play a key role in the onset of the disease state. Free oxygen radicals modify low-densiti... |
| In vitro and in vivo roles of 3H-1,2-dithiole-3-thione in lipopolysaccharide-induced toxicity and inflammatory injury |
2021 |
154 |
Lipopolysaccharide (LPS) is a bacterial endotoxin known for being critical in triggering septic shock. It is widely used for studies to understand systemic inflammation that mimics the inflammatory storm of human sepsis patients. 3H-1,2-dithiole-3-th... |
| Protection of HepG2 cells from acrolein toxicity by CDDO-Im via glutathione-mediated mechanism |
2013 |
2229 |
Acrolein is an environmental toxicant, mainly found in smoke released from incomplete combustion of organic matter. The compound is ubiquitously found in endogenous as well as exogenous environment. Several studies showed that exposure to acrolein ca... |
| Effects of carbon nanodots on TNF-a-induced inflammatory gene expression in mouse spleen tissue |
2022 |
163 |
The main cause of cardiovascular disease is known to be atherosclerosis, which is regulated by pro-inflammatory molecules such as IL-6, IL-1ß, Ho-1, MCP-1, TNF-a, VCAM1 IDT. The spleen is a vital part of the immune system and has been investigated fo... |
| A study of the effect of carbon nanodots on TNF-a induced human aortic endothelial inflammation |
2023 |
113 |
Atherosclerosis, a prevalent contributor to cardiovascular disease (CVD) on a global scale, is primarily triggered by inflammation, which plays a critical role in initiating the disease process. This inflammatory response leads to endothelial cell dy... |