A study of the effect of carbon nanodots on proinflammatory cytokine TNF-a induced endothelial dysfunction.
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Sarah Belperain (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
- Advisor
- Zhenquan Jia
Abstract: Cardiovascular disease (CVD) has become an increasingly important topic in the field of medical research due to the steadily increasing rates of mortality caused by this disease [1]. With recent advancements in nanotechnology, a push for new, novel treatments for CVD utilizing these new materials has begun. Carbon Nanodots (CNDs), are a new form of nanoparticles that have been coveted due to the green synthesis method, biocompatibility, fluorescent capabilities and potential anti-antioxidant properties. With much research pouring into CNDs being used as bioimaging and drug delivery tools, little studies have been completed on their anti-inflammatory potential, especially in the cardiovascular system. Atherosclerosis begins initially by endothelial cell inflammation. The cause of this inflammation can come from many sources; one being tumor necrosis factor (TNF-a), which can not only trigger inflammation, but prolong its existence by causing a storm of pro-inflammatory cytokines. This study investigated the ability of CNDs to attenuate TNF-a induced inflammation in human microvascular endothelial cells (HMEC-1). Results show that CNDs reduce the expression of pro-inflammatory genes, mainly Interleukin-8 (IL-8), and Intercellular adhesion molecule-1 (ICAM), at the same time, increase heme oxygenase 1 (HO-1) gene expression. The uptake of CNDs by HMEC-1s was examined. Results from the studies involving channel blockers and endocytosis disruptors suggest that uptake takes place by endocytosis. [This abstract has been edited to remove characters that will not display in this system. Please see the PDF for the full abstract.]
A study of the effect of carbon nanodots on proinflammatory cytokine TNF-a induced endothelial dysfunction.
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Created on 5/1/2020
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Additional Information
- Publication
- Thesis
- Language: English
- Date: 2020
- Keywords
- Atherosclerosis, Carbon Nanodots, Endothelial Cell, TNF-Alpha
- Subjects
- Atherosclerosis $x Treatment
- Nanoparticles
- Endothelial cells
- Tumor necrosis factor