| Title | Date | Views | Brief Description |
|---|
| Regulation of Myosin II Isoform Localization and Activation during Insulin Stimulated Glucose Uptake in 3T3-L1 Adipocytes. |
2006 |
1783 |
Insulin stimulated glucose uptake is a critical component of glucose homeostasis. The studies presented here show that myosin IIA is actively recruited to the plasma membrane upon insulin stimulation. I also show that inhibiting the interaction of my... |
| The Role of Myosin II in GLUT4 Activity and Membrane Fusion during Insulin-Stimulated Glucose Uptake in 3T3-L1 Adipocytes. |
2006 |
2234 |
Insulin-stimulated glucose uptake is a vital physiological process, which requires the translocation and fusion of insulin sensitive glucose transporter (GLUT4) vesicles from intracellular pools to the plasma membrane. Previous studies have implicate... |
| Characterization of the role of myosin II during insulin-stimulated glucose uptake in 3T3-L1 adipocytes |
2010 |
2832 |
Insulin-stimulated glucose uptake requires the activation of the nonmuscle motor protein myosin II. Our previous studies using pharmacological inhibitors suggest that insulin signaling results in the phosphorylation of myosin IIA during insulin-stimu... |
| Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes |
2012 |
627 |
Insulin stimulated glucose uptake in adipocytes requires the co-localization of myosin IIA (myoIIA) and glucose transporter 4 (GLUT4) at the plasma membrane. Our previous studies have shown that glucose uptake decreases dramatically if either GLUT4 o... |
| The role of increased reactive oxygen species on 3T3-L1 preadipocytes differentiation |
2012 |
53 |
Differentiation of preadipocytes plays an important role in human physiology by accommodating adipocyte expansion and maintaining energy homeostasis. Any process that interferes with preadipocytes differentiation could alter energy homeostasis. In ou... |
| The role of reactive oxygen species in insulin resistance |
2013 |
995 |
Insulin resistance and type II diabetes mellitus are major public health issues in the U.S.; more specifically insulin resistance is strongly correlated with obesity. Multiple factors influence insulin resistance such as hyperglycemic conditions and ... |
| Determining how myosin II affects GLUT4 docking and fusion to the plasma membrane in 3T3-L1 adipocytes |
2019 |
110 |
Myosin II is required for GLUT4 mediated glucose uptake in 3T3-L1 adipocytes. Previous studies from our lab have shown that myosin IIA and GLUT4 are stimulated to translocate to the plasma membrane from a perinuclear region upon insulin stimulation. ... |
| The role of naringenin on ERRa and adipocyte metabolism |
2019 |
132 |
Obesity is a metabolic disorder that is characterized by an increase in adipocyte number and size. The increase in lipid accumulation is due to an increase in glucose uptake and an imbalance between lipogenesis and lipolysis. Many factors regulate li... |
| A potential role for naringenin in reversing tamoxifen resistance in MCF-7 breast cancer cells |
2012 |
43 |
Tamoxifen has been used as an effective treatment against breast cancer for over 30 years. However, tamoxifen resistance has become a major hurdle to effective treatment. Previous studies have implicated up-regulation of the PI3K and MAPK pathways as... |
| Analysis of molecular target(s) of naringenin in MCF-7 breast cancer cells |
2014 |
820 |
Estrogen receptor (ER) antagonists such as tamoxifen have been used successfully to treat ER+ breast cancers for more than 30 years. Tamoxifen targets the ER and blocks the binding of estrogen thus preventing up-regulation of estrogen responsive gene... |
| Targeting multiple proliferation pathways as a novel breast cancer treatment |
2013 |
833 |
Estrogen receptor alpha positive (ERa+) breast cancer cells proliferate and survive by utilizing multiple pathways. Thus, combination chemotherapies targeting multiple pathways may be used to decrease ERa+ breast cancer cell density. Tamoxifen (Tam),... |
| The role of myosin II in stabilizing actin tethers promoting GLUT4 exocytosis in 3T3-L1 adipocytes |
2018 |
212 |
Aberrant insulin signaling results in an impaired ability to clear glucose from the bloodstream, which progresses to type II diabetes mellitus once insulin stimulation no longer results in a significant decrease in blood glucose levels. GLUT4 is the ... |