| Title | Date | Views | Brief Description |
|---|
| Goldenseal: a case study on LC-MS profiling to identify synergists |
2011 |
5494 |
The purported activity of goldenseal, Hydrastis canadensis L., against a plethora of disease states is largely attributed to the presence of the benzoisoquinoline alkaloid berberine in the plant. However, goldenseal crude extracts showed better inhib... |
| Identification, quantification and investigation of anti-inflammatory effects of Echinacea purpurea constituents |
2012 |
5087 |
Echinacea is among the top selling botanical medicines in the United States. Clinical trials have yielded contradictory reports on the efficacy of Echinacea preparations for treatment of colds, influenza, and inflammation, perhaps due to inconsistenc... |
| Dual sources of antimicrobial activity of Anemopsis californica : plant and endophytic fungi |
2014 |
3741 |
Anemopsis californica is a plant native to the southwestern United States and northern Mexico that has been used by many Native American tribes to alleviate pain and inflammation and to treat infection. Limited research has examined the chemical comp... |
| Analytical development for analysis of American ginseng and multiple agriculturual chemicals from soil |
2013 |
2331 |
Ginseng has been used for thousands of years as an herbal remedy for many common ailments. Ginsenosides from ginseng have shown a wide range of biological effects, including antioxidant and anti-cancer properties. The goal of this project was to deve... |
| Inhibiting antimicrobial resistance in Staphylococcus aureus using natural products |
2013 |
3710 |
Since the treatment of infections with antibiotics, Staphylococcus aureus has developed resistance to antimicrobial agents. Methicillin-resistant S aureus (MRSA) contributes significantly to the healthcare burden of both hospital and community infect... |
| Exploration of quorum sensing inhibition in gram positive bacterial pathogens using mass spectrometry |
2015 |
2650 |
Antibiotics have been used as the primary treatment for bacterial infections since the 1940’s. Unfortunately, the use and misuse of antibiotics has led to the proliferation of antibiotic-resistant bacteria and resulted in the loss of antibiotic effic... |
| Chemical Composition and Anti-proliferative Activity of Several Medicinal Plants |
2008 |
8418 |
Plants are valuable sources of medicinal compounds and their use for healing is well known from ancient times. Natural drugs obtained from plants represent about 25% of the prescription drug market in the United States. Plants have a long history of ... |
| A HPLC/ESI-MS method developed and validated to evaluate the quantity, identity, and stability of the alkylamides in ethanolic extracts of Spilanthes acmella |
2007 |
12422 |
"In order to evaluate the efficacy of herbal drugs, there need to be ways to qualitatively and quantitatively determine the constituents and their concentrations in various products. Spilanthes is a popular herbal extract which is used traditionally ... |
| Identification and stability of anthocyanins in Plantago lanceolata |
2007 |
4715 |
"Several laboratories have analyzed the content and stability of anthocyanins from foods and flowering plants ranging from potatoes to petunias. Previous research in the Cech and Lacey laboratories tentatively identified anthocyanins in Plantago lanc... |
| Antimicrobial compounds from endophytic fungi of goldenseal (Hydrastis canadensis) |
2016 |
1182 |
With this study, we explored the potential role of fungal endophytes in the antimicrobial activity of the medicinal plant goldenseal, Hydrastis canadensis L. (Ranunculaceae). A total of 23 fungal cultures were obtained from surface-sterilized samples... |
| Studies on bacterial Efflux pump inhibitors in land plants |
2015 |
2336 |
The research presented in this dissertation deals with the phenomena of bacterial efflux pump inhibition by natural products and plant extracts. Bacterial efflux pumps are active transport proteins, primarily deriving their energy source from the pro... |
| Glycerol for improving solubility and evaluation of antimicrobial activity for natural products |
2016 |
1881 |
With this study, we aimed to improve solubility and provide enhanced evaluation of antimicrobial activity with the addition of glycerol as a co-solvent with DMSO. The antimicrobial activities of glycerol and DMSO were evaluated against Staphylococcus... |
| Rapid and improved assay of surfactins from Bacillus subtilis, 203R via UPLC-ESI-MS |
2018 |
544 |
To better bridge research with commercialization, this project sought to develop an improved analytical method for the assay of biosurfactants known as surfactins from Bacillus subtilis. We sought to compare levels of production from various strains ... |
| Bioinformatic strategies to understand the complexities of medicinal natural product mixtures |
2019 |
934 |
Compounds from natural sources, as well as those inspired by them, represent the majority of small molecule drugs on the market today. Plants, owing to their complex biosynthetic pathways, are poised to synthesize diverse secondary metabolites that s... |
| Identification of commensal bacteria autoinducing peptides with ultrahigh performance liquid chromatography - high resolution mass spectrometry |
2020 |
282 |
Staphylococcus aureus is an opportunistic pathogen that has become an increasing issue over the years due to its acquired resistance to different antibiotics such as methicillin. The development of resistance has sparked interest in finding new ways ... |
| Interaction metabolomics to discover synergists in natural product mixtures |
2022 |
694 |
Mass spectrometry metabolomics has become increasingly popular as an integral aspect of studies designed to identify active compounds from natural product mixtures. Classical metabolomics data analysis approaches do not consider the possibility that ... |
| New strategies to identify bioactive compounds from complex matrices to combat drug-resistant bacterial infections |
2018 |
463 |
The use of plants as medicine for human health has been documented on 5000-year-old Sumerian clay slabs, which also serve as the first evidence of written language. From 1940 to 2014, 83 % of small molecule anti-cancer treatments and 67 % of small-mo... |
| Exploration of interactions between commensal Staphylococci and methicillin-resistant Staphylococcus aureus |
2021 |
90 |
Methicillin-resistant Staphylococcus aureus (MRSA) is a multidrug-resistant superbug that causes infections in immunocompromised and immunocompetent individuals. This infection causes more than 300,000 infections and more than 10,000 deaths, with hea... |
| Optimization of ambuic acid as an anti-virulence agent against methicillin-resistant Staphylococcus aureus |
2020 |
336 |
Drug resistant bacterial infections are an increasing threat to human health across the globe. Current treatment options for combating these infections primarily rely on antibiotics. Overreliance on the antibiotic therapy continues to accelerate the ... |
| Targeted analogue detection from Pestalotiopsis microspora using molecular networking and mass defect filtering: towards the development of new anti-virulence leads against methicillin resistant Staphylococcus aureus |
2019 |
429 |
Effective tools are needed to enable prioritization of lead molecules in natural products drug discovery research. As the field of mass spectrometry continues to advance, more people have access to high-resolution instruments, and more researchers re... |
| Identification of adulteration in botanical samples with untargeted mass spectrometry metabolomics |
2019 |
416 |
According to the 2017 Council for Responsible Nutrition survey, botanicals makeup 39% of the total dietary supplement usage in the United States. The use of dietary supplements in general has increased by 8% since 2015, and there is a need to ascerta... |
| New leads against drug-resistant organisms : shifting the focus in discovery towards rapid phenotypic screening and mechanism of action |
2022 |
180 |
Over the past century, antibiotic therapy has been successful in nearly eliminating a former leading cause of death. Mortality records from the past 100 years in the US show a decrease from 46% of deaths due to infectious diseases, to just 3% in 2010... |