Cech, Nadja

uncg

There are 18 item/s.

TitleDateViewsBrief Description
Chemical Composition and Anti-proliferative Activity of Several Medicinal Plants 2008 7699 Plants are valuable sources of medicinal compounds and their use for healing is well known from ancient times. Natural drugs obtained from plants represent about 25% of the prescription drug market in the United States. Plants have a long history of ...
A HPLC/ESI-MS method developed and validated to evaluate the quantity, identity, and stability of the alkylamides in ethanolic extracts of Spilanthes acmella 2007 11182 "In order to evaluate the efficacy of herbal drugs, there need to be ways to qualitatively and quantitatively determine the constituents and their concentrations in various products. Spilanthes is a popular herbal extract which is used traditionally ...
Identification and stability of anthocyanins in Plantago lanceolata 2007 4115 "Several laboratories have analyzed the content and stability of anthocyanins from foods and flowering plants ranging from potatoes to petunias. Previous research in the Cech and Lacey laboratories tentatively identified anthocyanins in Plantago lanc...
Goldenseal: a case study on LC-MS profiling to identify synergists 2011 4698 The purported activity of goldenseal, Hydrastis canadensis L., against a plethora of disease states is largely attributed to the presence of the benzoisoquinoline alkaloid berberine in the plant. However, goldenseal crude extracts showed better inhib...
Identification, quantification and investigation of anti-inflammatory effects of Echinacea purpurea constituents 2012 4744 Echinacea is among the top selling botanical medicines in the United States. Clinical trials have yielded contradictory reports on the efficacy of Echinacea preparations for treatment of colds, influenza, and inflammation, perhaps due to inconsistenc...
Analytical development for analysis of American ginseng and multiple agriculturual chemicals from soil 2013 1862 Ginseng has been used for thousands of years as an herbal remedy for many common ailments. Ginsenosides from ginseng have shown a wide range of biological effects, including antioxidant and anti-cancer properties. The goal of this project was to deve...
Inhibiting antimicrobial resistance in Staphylococcus aureus using natural products 2013 3415 Since the treatment of infections with antibiotics, Staphylococcus aureus has developed resistance to antimicrobial agents. Methicillin-resistant S aureus (MRSA) contributes significantly to the healthcare burden of both hospital and community infect...
Dual sources of antimicrobial activity of Anemopsis californica : plant and endophytic fungi 2014 3036 Anemopsis californica is a plant native to the southwestern United States and northern Mexico that has been used by many Native American tribes to alleviate pain and inflammation and to treat infection. Limited research has examined the chemical comp...
Studies on bacterial Efflux pump inhibitors in land plants 2015 1980 The research presented in this dissertation deals with the phenomena of bacterial efflux pump inhibition by natural products and plant extracts. Bacterial efflux pumps are active transport proteins, primarily deriving their energy source from the pro...
Exploration of quorum sensing inhibition in gram positive bacterial pathogens using mass spectrometry 2015 2026 Antibiotics have been used as the primary treatment for bacterial infections since the 1940’s. Unfortunately, the use and misuse of antibiotics has led to the proliferation of antibiotic-resistant bacteria and resulted in the loss of antibiotic effic...
Antimicrobial compounds from endophytic fungi of goldenseal (Hydrastis canadensis) 2016 711 With this study, we explored the potential role of fungal endophytes in the antimicrobial activity of the medicinal plant goldenseal, Hydrastis canadensis L. (Ranunculaceae). A total of 23 fungal cultures were obtained from surface-sterilized samples...
Glycerol for improving solubility and evaluation of antimicrobial activity for natural products 2016 1069 With this study, we aimed to improve solubility and provide enhanced evaluation of antimicrobial activity with the addition of glycerol as a co-solvent with DMSO. The antimicrobial activities of glycerol and DMSO were evaluated against Staphylococcus...
New strategies to identify bioactive compounds from complex matrices to combat drug-resistant bacterial infections 2018 48 The use of plants as medicine for human health has been documented on 5000-year-old Sumerian clay slabs, which also serve as the first evidence of written language. From 1940 to 2014, 83 % of small molecule anti-cancer treatments and 67 % of small-mo...
Rapid and improved assay of surfactins from Bacillus subtilis, 203R via UPLC-ESI-MS 2018 238 To better bridge research with commercialization, this project sought to develop an improved analytical method for the assay of biosurfactants known as surfactins from Bacillus subtilis. We sought to compare levels of production from various strains ...
Bioinformatic strategies to understand the complexities of medicinal natural product mixtures 2019 34 Compounds from natural sources, as well as those inspired by them, represent the majority of small molecule drugs on the market today. Plants, owing to their complex biosynthetic pathways, are poised to synthesize diverse secondary metabolites that s...
Targeted analogue detection from Pestalotiopsis microspora using molecular networking and mass defect filtering: towards the development of new anti-virulence leads against methicillin resistant Staphylococcus aureus 2019 125 Effective tools are needed to enable prioritization of lead molecules in natural products drug discovery research. As the field of mass spectrometry continues to advance, more people have access to high-resolution instruments, and more researchers re...
Identification of adulteration in botanical samples with untargeted mass spectrometry metabolomics 2019 101 According to the 2017 Council for Responsible Nutrition survey, botanicals makeup 39% of the total dietary supplement usage in the United States. The use of dietary supplements in general has increased by 8% since 2015, and there is a need to ascerta...
Optimization of ambuic acid as an anti-virulence agent against methicillin-resistant Staphylococcus aureus 2020 10 Drug resistant bacterial infections are an increasing threat to human health across the globe. Current treatment options for combating these infections primarily rely on antibiotics. Overreliance on the antibiotic therapy continues to accelerate the ...