Croatt, Mitchell

uncg

There are 6 item/s.

TitleDateViewsBrief Description
Approaches towards the biomimetic synthesis of 9-hydroxypinoresinol analogs: a stepping point in the development of a new anti-seizure drug 2013 1945 A recently isolated natural compound, Petaslignolide A, from the leaves of Petasites japonicas, has shown to be an effective neuroprotecting agent because of its antioxidant and anti-seizure activity. Recent studies have shown that the anti-seizure a...
Investigations in the synthesis of isocarbacyclin analogs involving transition metal catalysis with explorations into palladium catalyzed decarboxylation. 2013 1407 Isocarbacyclin, a synthetic form of prostacyclin, has been recognized as a potential neuroprotective drug which could be used for patients of ischaemic stroke. The first goal described in this thesis was to create a new set of analogs of isocarbacycl...
Design, synthesis and biological evaluation of GPR55 agonists and resorcylic acid lactone-based analogues as TAK-1 inhibi 2015 679 GPR55 is a potential target for treating various illnesses. Inhibition of this membrane-bound G protein-coupled receptor may potentially alleviate inflammatory and neuropathic pain and treat osteoporosis and cancer. Radiolabelling of a potent and sel...
Design, synthesis, and structure-activity relationships of GPR35 agonists and antagonists and design, synthesis, and anti-microbial evaluation of pyrazole derivatives 2015 359 GPR35, a G protein-coupled receptor (GPCR), was discovered and specified as an orphan receptor in 1998. GPR35 has been described as a prospective therapeutic target as a result of its association with many diseases including type-2 diabetes, nocicept...
Synthesis of potential potent antagonist of G-Protein coupled receptors 2016 36 GPR55, is a G-protein coupled receptor (GPCR), that was first discovered in 1990 and deorphanized in 2006. The homology model of the receptor in the active and inactive state is based off of the ß – adrenergic receptor. A potent agonist of GPR55 is t...
Synthesis and biological evaluation of potent neuroprotective agents against stroke and research on a novel type of decarboxylation reaction 2017 60 Isocarbacyclin is a valuable synthetic target that has been recognized as a potential neuroprotective agent against ischemic stroke. Herein we describe a step-economical synthesis of isocarbacyclin in an enantioselective fashion. The synthetic route ...