| Title | Date | Views | Brief Description |
|---|
| Design, synthesis, and structure-activity relationships of GPR35 agonists and antagonists and design, synthesis, and anti-microbial evaluation of pyrazole derivatives |
2015 |
933 |
GPR35, a G protein-coupled receptor (GPCR), was discovered and specified as an orphan receptor in 1998. GPR35 has been described as a prospective therapeutic target as a result of its association with many diseases including type-2 diabetes, nocicept... |
| Design and development of novel reactions utilizing dienes and carbene intermediates |
2020 |
242 |
The design and development of novel reactions are long-standing goals within the synthetic community. Specifically, reactions that can give molecularly complex products through the manipulation of readily available starting materials are of considera... |
| Internal base-directed regioselective aromatic Claisen rearrangements of imine derivatives |
2024 |
65 |
The aromatic Claisen rearrangement is a powerful sigmatropic reaction which unfortunately lacks regioselectivity. In this work, various tetralone-based imine derivative substrates featuring an intramolecular base were investigated to better understan... |
| Approaches towards the biomimetic synthesis of 9-hydroxypinoresinol analogs: a stepping point in the development of a new anti-seizure drug |
2013 |
2312 |
A recently isolated natural compound, Petaslignolide A, from the leaves of Petasites japonicas, has shown to be an effective neuroprotecting agent because of its antioxidant and anti-seizure activity. Recent studies have shown that the anti-seizure a... |
| Design, synthesis and biological evaluation of GPR55 agonists and resorcylic acid lactone-based analogues as TAK-1 inhibi |
2015 |
1124 |
GPR55 is a potential target for treating various illnesses. Inhibition of this membrane-bound G protein-coupled receptor may potentially alleviate inflammatory and neuropathic pain and treat osteoporosis and cancer. Radiolabelling of a potent and sel... |
| Investigations in the synthesis of isocarbacyclin analogs involving transition metal catalysis with explorations into palladium catalyzed decarboxylation. |
2013 |
1739 |
Isocarbacyclin, a synthetic form of prostacyclin, has been recognized as a potential neuroprotective drug which could be used for patients of ischaemic stroke. The first goal described in this thesis was to create a new set of analogs of isocarbacycl... |
| Synthesis and biological evaluation of potent neuroprotective agents against stroke and research on a novel type of decarboxylation reaction |
2017 |
513 |
Isocarbacyclin is a valuable synthetic target that has been recognized as a potential neuroprotective agent against ischemic stroke. Herein we describe a step-economical synthesis of isocarbacyclin in an enantioselective fashion. The synthetic route ... |
| Protodecarboxylation of ß-keto-acrylates and synthesis of isomaleimides by dehydration of maleamic acids using methanesulfonyl chloride |
2021 |
187 |
The development of unique reaction conditions for the protodecarboxylation of P-keto-acrylic acids is described. This expansion on previous work ameliorates the requirement of added water, affording a homogeneous reaction system. As an unexpected dis... |
| Synthesis of potential potent antagonist of G-Protein coupled receptors |
2016 |
281 |
GPR55, is a G-protein coupled receptor (GPCR), that was first discovered in 1990 and deorphanized in 2006. The homology model of the receptor in the active and inactive state is based off of the ß – adrenergic receptor. A potent agonist of GPR55 is t... |
| Palladium catalyzed dehydration of primary amides: a step economical synthesis of Vildagliptin |
2021 |
2412 |
The development of reactions that facilitate a concise path to chemical complexity has long been a focus within the synthetic community. Specifically, the use of readily available starting materials towards efficient routes to chemically relevant mol... |
| Use of cyanocarbenes for the synthesis of donor-acceptor cyclopropanes |
2024 |
31 |
The development of novel reactions is a crucial facet of organic synthesis. Cyclopropanes are a difficult moiety to produce in organic syntheses due to their large ring strain yet can be found in many natural products and are a common moiety in pharm... |