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Theses & Dissertations

Submissions

Katula, Karen

uncg

There are 10 item/s.

TitleDateViewsBrief Description
The Effect of Folate Deficiency on the Wnt Signaling Pathway 2008 876 Folate is an essential dietary vitamin involved in methylation reactions and DNA synthesis. Insufficient dietary folate has been associated with various developmental and adult diseases such as neural tube defects and colorectal cancer. The basis for...
Effects of altered folate metabolism on specific gene expression in the developing Xenopus embryo 2006 928 "Approximately 1 out of every 2000 births in the United States is affected by neural tube defects. The most well-known environmental cause of neural tube malformation is folate deficiency in pregnant women. The underlying mechanism for this relation...
Regulation of dickkopf-1(Dkk-1) promoter sequences under various growth conditions 2006 949 "The goal of this study was to determine what region of the Dkk-1 promoter was required for expression of the Dkk-1 gene under different growth conditions. Dkk-1 promoter activity was analyzed in NIH3T3 cell lines stably transfected with luciferase ...
Possible involvement of NF-?B in the response of cells to folate deficiency. 2009 257 Folate, a water soluble B vitamin, serves as a methyl donor for the synthesis of nucleotides and methionine. Folate deficiency has been linked to a variety of health problems that include developmental defects, cancer and neurological diseases. The r...
The Effects of Folate Deficiency on on E-cadherin and ß-catenin in Colon Epithelial Cells 2009 463 Folate deficiency has been linked to multiple health problems including neural tube defects and cancer, especially colorectal cancer. Folate is an essential dietary vitamin that is required for DNA synthesis and cellular methylation reactions. The me...
The effects of folate deficiency on E-cadherin and ß-catenin in colon epithelial cells. 2009 463 Folate deficiency has been linked to multiple health problems including neural tube defects and cancer, especially colorectal cancer. Folate is an essential dietary vitamin that is required for DNA synthesis and cellular methylation reactions. The me...
Characterization and regulation of Wnt5a alternate promoters A and B 2011 1015 WNT5A is an extracellular glycoprotein that activates several Wnt signaling pathways important in cancer. Significantly, Wnt5a expression is altered in numerous cancers. Little is known about Wnt5a gene regulation but current data indicate that misre...
Expression of Wnt5a alternative promoters A and B during cancer progression and cellular differentiation 2012 506 WNT5A is a secreted glycoprotein that plays an important role in cellular differentiation, cell homeostasis and development. It is also misregulated in numerous cancer cell types. The Wnt5a gene generates multiple transcripts from distinct promoters ...
Role of DNA methylation in WNT5A Promoter B expression in Osteosarcoma (SaOS-2) cells. 2013 9 WNT5A, a member of the WNT family of secreted proteins, activates the non-canonical WNT pathway, regulates developmental events and is involved in tissue homeostasis. Misregulation of WNT5A has been associated with various types of cancer including p...
Aberrant DNA methylation and patterns of histone modifications at the WNT5A Promoter B in osteosarcoma cells 2014 16 WNT5A is a secreted ligand involved in differentiation, proliferation, cell movement and apoptosis. WNT5A is often misregulated in cancer and is known to be involved in cancer metastasis. The focus of this study was on the possible epigenetic regulat...