| Title | Date | Views | Brief Description |
|---|
| Regulation of cytochrome P450 2A6 and phase II enzymes by unsaturated aldehydes |
2009 |
1539 |
Human Phase I and Phase II drug metabolizing enzymes are known to interact
with foreign chemicals that enter the body as a defense mechanism, however, it is often
the case that unwanted interactions can occur. Phase I metabolism may form reactive
... |
| The Adaptive Nature of Cytochrome P4502E1-Mediated Ethanol Oxidation: Implications on the Overall Catalytic Scheme |
2010 |
2025 |
The Cytochrome P450 family is a class of enzymes responsible for the breakdown of about 75% of the drugs that are administered (18). The 2E1 isoform of this family is known as the "ethanol-inducible" member, because ethanol has demonstrated the capac... |
| Inhibition of Cytochrome P450 2E1, Cytochrome P450 3A6 and Cytochrome P450 2A6 by Citrus Essential Oils |
2010 |
6852 |
Cytochrome P450 enzymes in the liver catalyze reactions involving the reduction of molecular oxygen and the oxidation of organic substrates. In some cases the resulting products may have the potential to contribute to oxidative stress within this org... |
| Interactions of echinacea and spilanthes with human metabolizing systems |
2006 |
2426 |
"Increasing use of herbal products in recent years demand further studies relating to their safety and efficacy. Since cytochrome P450 enzymes play a major role in drug metabolism, studying their interactions with herbal extracts would be an importan... |
| The reaction of alternate oxidants with cytochrome P450BM3 and mutants generates spectrally detectable, high valent iron intermediates |
2006 |
1646 |
"The Cytochrome P450 family serves as the forefront for xenobiotic metabolism in the human body. An understanding of the mechanism behind this enzyme family is a necessity for later research in the areas of pharmaceuticals and biochemistry. It has be... |
| Effects of herbal products on human P450 2E1 activity |
2006 |
1494 |
"Cytochromes P450s are present in all forms of life and play an important role in the oxidative transformation of endogeneous and exogeneous molecules. P450 2E1 is a major isoform of cytochrome. The consumption of herbal products in the world is incr... |
| Isotopic labeling of heme in dehaloperoxidase and CYP102A2 for NMR studies |
2007 |
2848 |
"13C NMR has been shown to be a powerful tool for probing the electronic distribution in paramagnetic hemes and hemoproteins. Methods that can measure the coordination state and electronic structure of the paramagnetic hemes and hemoproteinscan be v... |
| Inhibition of cytochrome P450 subfamilies 2E1, 2A6, & 2B4 using the Amazon acai berry, Euterpe oleracea |
2010 |
3871 |
The ability for cytochrome P450s to metabolize drugs and other compounds foreign to the body has led scientists to monitor the metabolites formed from the metabolic cycle of xenobiotics as they can prove potentially fatal if produced in large quantit... |
| Effects of açaí berry (Euterpe oleracea) extracts on human antioxidant systems and drug metabolism |
2015 |
1771 |
The source and sink of reactive oxygen species are diverse and so are the control mechanisms to counteract them. Sources may be exogenous or endogenous from normal metabolic pathways. Similarly, the sink could be a simple radical scavenging event by ... |
| Analysis of ginger root essential oil and hydrosol: CYP450 inhibition |
2015 |
1620 |
Former researches showed ginger extracts could contribute to hepatic protection. Two species of cytochrome P450 enzymes, CYP2E1 and CYP2A6, are both important heme-containing liver enzymes for hepatictoxicology via metabolizing small organic molecule... |
| Inhibition of cytochrome P4502E1 by lemongrass and the primary aldehyde constituent of lemongrass, citral |
2010 |
4010 |
Cytochrome P4502E1, the ethanol-inducible form, metabolizes and activates a significant number of substrates to more toxic products and the induction of CYP2E1 by ethanol is thought to result in increased oxidative stress in hepatocytes. One proposed... |
| Isotopic probe for spectroscopic studies of heme |
2009 |
2566 |
Cytochrome P450 enzymes (P450s) are heme containing monooxygenases with great potential in applications focused in biotechnological areas. An understanding of the precise chemical process behind this enzyme is essential in research in the areas of ph... |
| Inhibition of Cytochrome P450 2E1 and Cytochrome P450 2A6 by essential oils: tarragon (Artemisia dracunculus) and basil (Ocimum basilicum) |
2014 |
2070 |
Cytochrome P450 enzymes are involved in the metabolism of foreign substances that are present within living organisms. These P450s are classified as Phase I metabolizing enzymes that are found mainly in the liver, they belong to a superfamily of heme... |
| Investigating the inhibition of cytochrome P450 isoform 1A1 by açai berry (Euterpe oleracea) extracts using a bioassay guided fractionation approach |
2016 |
929 |
Xenobiotic metabolism is an important process within the human body, as it alters large, foreign, hydrophobic molecules and prepares them for excretion. This process is largely carried out in the liver and is accomplished by a superfamily of heme-con... |
| Investigation into the inhibition of drug-metabolizing Cytochrome P450 isoenzymes by the Amazonian acai berry (Euterpe oleracea) |
2014 |
2445 |
Natural products, often containing a magnitude of unidentified constituents, have come under scrutiny in order to understand their effects on the human body. Cytochrome P450 enzymes, due to their non-selective nature, are highly susceptible to interf... |
| Inhibition of Cytochrome P450 2C9 by essential oils |
2015 |
4694 |
Cytochrome P450 enzymes (CYP450) are the prominent member of a family of xenobiotic metabolizing enzymes that are collectively referred to as Phase 1 enzymes (1). Phase 1 enzymes are responsible for taking reactive oxygen molecules and introducing th... |
| Cytochrome P450’s and the effects upon the addition of undecylenic aldehyde |
2016 |
639 |
Cytochrome P450’s are vital enzymes for the metabolism of chemicals that are foreign to the human body. By altering the activity of these enzymes through enzyme inhibition, it is possible to alter rates of metabolism of these so-called xenobiotics ma... |
| The effects of kudzu (Pueraria lobata) on various cytochrome P450s |
2015 |
917 |
The significant impact that this project is desired to have is to provide fundamental knowledge regarding the use of kudzu products for medicinal purposes, as it relates to antioxidant and anti-inflammatory effects. This is anticipated to be achieved... |