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Effects of herbal products on human P450 2E1 activity

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Yingqing Wang (Creator)
Institution
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/
Advisor
Gregory Raner

Abstract: "Cytochromes P450s are present in all forms of life and play an important role in the oxidative transformation of endogeneous and exogeneous molecules. P450 2E1 is a major isoform of cytochrome. The consumption of herbal products in the world is increasing greatly during last decade. The concurrent use of herbal products with prescription carries a risk for unanticipated adverse herb-drug pharmacokinetic interaction, particularly as a result of cytochrome P450 2E1 inhibition. In this research, the preparation and purification of extract of Green Tea, Goldenseal, Echinacea and Spilanthes was performed. In addition, P450 2E1 related activities were to be examined with respect to inhibition by four potential different inhibitors, including GTE, Goldenseal, Echinacea and Spilanthes. The objective of this research is to determine whether herbal products, such as GTE, Goldenseal, Echinacea and Spilanthes, inhibit the activity of the human P450 2E1 enzymes."--Abstract from author supplied metadata.

Additional Information

Publication
Thesis
Language: English
Date: 2006
Keywords
Cytochromes, P450s, oxidative transformation, molecules, herbal products, Green Tea, Goldenseal, Echinacea, Spilanthespharmacokinetic
Subjects
Herbs--Therapeutic use--Research
Drug-herb interactions