Multiple Kinase Involvement in the Regulation of Vascular Growth

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Shaquria Adderly (Creator)

Chintamani N. Joshi (Creator)

Danielle N. Martin (Creator)

Shayna Mooney (Creator)

David A. Tulis (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: The initial discovery of protein phosphorylation as a regulatory mechanism for the control of glycogen metabolism has led to intense interest of protein phosphorylation in regulating protein function (Cohen et al. 2001). Kinases play a variety of roles in many physiological processes within cells and represent one of the largest families in the human genome with over 500 members comprising protein serine/threonine tyrosine and dual-specificity kinases (Manning et al. 2002). Phosphorylation of proteins is one of the most significant signal transduction mechanisms which regulate intracellular processes such as transport growth metabolism apoptosis cystoskeletal arrangement and hormone responses (Bononi et al. 2011; Heidenreich et al. 1991; Manning et al. 2002; Pawson et al. 2000). As such abnormal phosphorylation of proteins can be either a cause or a consequence of disease. Kinases are regulated by activator and inhibitor proteins ligand binding and phosphorylation by other proteins or via autophosphorylation (Hanks et al. 1991; Hug et al. 1993; Scott 1991; Taylor et al. 1990; Taylor et al. 1992). Since kinases play key functions in many cellular processes they represent an attractive target for therapeutic interventions in many disease states such as cancer inflammation diabetes and arthritis (Cohen et al. 2010; Fry et al. 1994; Karin 2005; Mayers et al. 2005). In particular the serine/threonine family of kinases comprises approximately 125 of the 500 family of kinases and includes the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) the cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) and protein kinase C (PKC). These kinases are implicated in the regulation of cell growth and are the focus of this current study.

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Ch. 6 in Advances in Protein Kinases ed. G. Da Silva Xavier. New York: InTech Open Access Publishers 2012: 131-150

Language: English

Date: 2013

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