David A. Tulis

There are 7 included publications by David A. Tulis :

TitleDateViewsBrief Description
Anti-growth properties of BAY 41-2272 in vascular smooth muscle cells 2011 55993 Vascular smooth muscle (VSM) growth is integral in the pathophysiology of blood vessel diseases and identifying approaches that have capacity to regulate VSM growth is critically essential. Cyclic nucleotide signaling has been generally considered pr...
Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries 2011 55993 Objective—Arginase stimulates the proliferation of cultured vascular smooth muscle cells VSMCs); however the influence of arginase on VSMC growth in vivo is not known. This study nvestigated the impact of arginase on cell cycle progression and neoi...
The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through anti-proliferative and pro-apoptotic effects 2011 55993 Guanosine-specific cyclic nucleotide signaling is suggested to serve protective actions in the vasculature; however the influence of selective pharmacologic modulation of cyclic guanosine monophosphate (GMP)-synthesizing soluble guanylate cyclase (sG...
DINITROBENZENES STIMULATE ELECTRON FLUX WITHIN NEURONAL NITRIC OXIDE SYNTHASE IN THE ABSENCE OF CALMODULIN 2013 55993 Efficient electron transfer and conversion of L-arginine to L-citrulline and nitric oxide NO●) by neuronal nitric oxide synthase (nNOS) requires calmodulin (CaM) binding. The resent study focused on electron transfer ability of resting state CaM-fr...
LOCAL ADMINISTRATION OF CARBON MONOXIDE INHIBITS NEOINTIMA FORMATION IN BALLOON INJURED RAT CAROTID ARTERIES 2013 55993 Recent studies indicate that systemic induction of heme oxygenase-1 (HO-1) which oxidatively degrades heme into iron biliverdin and carbon monoxide (CO) or adenoviral-mediated gene transfer of HO-1 inhibits neointima formation after experimental vasc...
Multiple Kinase Involvement in the Regulation of Vascular Growth 2013 55993 The initial discovery of protein phosphorylation as a regulatory mechanism for the control of glycogen metabolism has led to intense interest of protein phosphorylation in regulating protein function (Cohen et al. 2001). Kinases play a variety of rol...
YC-1 Stimulates the Expression of Gaseous Monoxide-Generating Enzymes in Vascular Smooth Muscle Cells 2011 55993 The benzylindazole derivative 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1) is an allosteric stimulator of soluble guanylate cyclase (sGC) that sensitizes the enzyme to the gaseous ligands carbon monoxide (CO) and nitric oxide (NO). In t...