Synthesis of site specific DNA methylating compounds targeting pancreatic ß-cells

UNCW Author/Contributor (non-UNCW co-authors, if there are any, appear on document)
Lacey Marie Smith (Creator)
The University of North Carolina Wilmington (UNCW )
Web Site:
Sridhar Varadarajan

Abstract: This project involves synthesizing compounds that are capable of producing cytotoxic N3-methyladenine DNA adducts in pancreatic ß-cells. The compounds will consist of three units: 1) A cell targeting ligand, glucose, which is specific to the insulin producing pancreatic ß-cells, 2) a DNA methylating unit, Me-lex, which has been shown to selectively make N3-methyladenine adducts, and 3) linker component which will connect the two units previously mentioned. The linker portion is critical in the binding of the compounds to DNA as well as the ability of the compounds to be transported into the pancreatic ß-cells. Several stable analog compounds were synthesized to test the ability of the compounds to be transported selectively into pancreatic ß-cells and test their binding to DNA.

Additional Information

A Thesis Submitted to the University of North Carolina Wilmington in Partial Fulfillment of the Requirements for the Degree of Master of Science
Language: English
Date: 2009
Cancer--Chemotherapy--Research, DNA--Methylation, Molecular biology, Pancreatic beta cells--Research
DNA -- Methylation
Molecular biology
Pancreatic beta cells -- Research
Cancer -- Chemotherapy -- Research

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