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Varadarajan, Sridhar

uncw

There are 4 item/s.

TitleDateViewsBrief Description
Design and synthesis of DNA minor groove methylating compounds that target pancreatic 7-cells 2009 955 The design of compounds that form cytotoxic, non-mutagenic 3-methyladenine adducts in pancreatic ß-cells is being studied in this project for potential applications in the treatment of diseases such as diabetes and cancer. These compounds are compo...
Synthesis of compounds capable of producing cytotoxic N3-methyladenine DNA adducts in estrogen receptor positive cells 2009 1430 This project describes the design and synthesis of new compounds that are capable of targeting cells that express the estrogen receptor and producing cytotoxic N3-methyladenine DNA adducts in those cells. These compounds contain a reactive methylsu...
Modulation of lipid domain formation in mixed model systems by proteins and peptides 2009 490 The control of lipid domain formation in biological membranes has received limited consideration. This mechanism is quantitatively investigated using Monte Carlo computer simulations of a simple model system. Monte Carlo simulations are performed on ...
Synthesis of site specific DNA methylating compounds targeting pancreatic ß-cells 2009 852 This project involves synthesizing compounds that are capable of producing cytotoxic N3-methyladenine DNA adducts in pancreatic ß-cells. The compounds will consist of three units: 1) A cell targeting ligand, glucose, which is specific to the insulin ...