Schizophrenic-like neurocognitive deficits in children and adolescents with 22q11 deletion syndrome

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Thomas R. Kwapil, Associate Professor (Creator)
Kathryn Eve Lewandowski (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: 22q11.2 Deletion Syndrome (22q11DS) is the most common genetic microdeletion syndrome affecting humans. The syndrome is associated with general cognitive impairments and specific deficits in visual-spatial ability, non-verbal reasoning, and planning skills. 22q11DS is also associated with behavioral and psychiatric abnormalities, including a markedly elevated risk for schizophrenia. Research findings indicate that people with schizophrenia, as well as those identified as schizoptypic, show specific cognitive deficits in the areas of sustained attention, executive functioning, and verbal working memory. The present study examined such schizophrenic-like cognitive deficits in children and adolescents with 22q11DS (n?=?26) and controls (n?=?25) using a cross-sectional design. As hypothesized, 22q11DS participants exhibited deficits in intelligence, achievement, sustained attention, executive functioning, and verbal working memory compared to controls. Furthermore, deficits in attention and executive functioning were more pronounced in the 22q11DS sample relative to general cognitive impairment. These findings suggest that the same pattern of neuropsychological impairment seen in patients with schizophrenia is present in non-psychotic children identified as at-risk for the development of schizophrenia based on a known genetic risk marker. © 2006 Wiley-Liss, Inc.

Additional Information

Language: English
Date: 2007
22q11, 22q11 deletion syndrome, schizophrenia, schizotypy, cognitive, neurocognitive, psychology

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