The effects of peripherally administered 17-ß estradiol and BIBP3226, a NPY Y1 receptor antagonist, on food intake, body mass, reproductive development and behavior in female leptin-deficient ob/ob mice

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Elizabeth Ann Essick-Brookshire (Creator)
Institution
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/
Advisor
John Lepri

Abstract: Peripubertal, leptin-deficient ob/ob female mice were used in an investigation of exogenous estradiol (E2) and BIBP3226, a neuropeptide Y (NPY) antagonist acting at the Y1 receptor, on food consumption, body mass and sexual receptivity. The absence of leptin in the ob/ob model has been proposed to result in chronic hyperphagia due to high levels of NPY signaling. Research findings suggest that NPY Y1 receptors, whether located in the CNS or PNS, are likely candidates for mediating the orexigenic actions of NPY. Moreover, the lack of reproductive organ development characteristic of ob/ob mice is proposed herein to be consequent of excessively elevated NPY levels activating peripheral Y1 receptors. Reproductive organ development and function were restored by exogenous estradiol administration as well as by a combined treatment with BIBP3226 and E2, suggesting a role of E2 in mediating NPY's effects on caloric intake, reproductive development and sexual receptivity.

Additional Information

Publication
Thesis
Language: English
Date: 2008
Keywords
Leptin, neuropeptide Y, estrogen, ob/ob mice
Subjects
Neuropeptides--Research.
Neuropeptides--Physiological effect.
Leptin--physiology.
Obesity--Endocrine aspects.
Mice--Reproduction--Endocrine aspects.