Obionin B: an o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the order Pleosporales
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Tyler Graf, Research Scientist (Creator)
- Nicholas Oberlies, Patricia A. Sullivan Distinguished Professor of Chemistry (Creator)
- Cedric J Pearce, Adjunct Professor (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: A fungal extract (MSX 63619), from the Mycosynthetix library of over 50,000 fungi, displayed promising cytotoxicity against a human tumor cell panel. Bioactivity-directed fractionation led to the isolation of an o-pyranonaphthoquinone decaketide, which we termed obionin B (1). The structure of 1 was deduced via spectroscopic and spectrometric techniques. The IC50 value of 1 was moderate, ranging from 3 to 13 µM, depending on the cell line tested.
Obionin B: an o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the order Pleosporales
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Additional Information
- Publication
- Tetrahedron Letters, 2011, 52, pp 5128-5230
- Language: English
- Date: 2011
- Keywords
- Polyketide, Cytotoxicity, Pleosporales, o-Naphthoquinone