The effects of risperidone, an atypical antipsychotic, on the reeler mutant mouse, a potential model of schizophrenia

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Amanda K. Goode (Creator)
Institution
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/
Advisor
Walter Salinger

Abstract: "The reeler mutant mouse (rl/rl) has been proposed to be a behavioral model of schizophrenia. The purpose of the current research was to study the effects of the antipsychotic, risperidone, on the rl/rl, because if the rl/rl models schizophrenia, then risperidone should improve its cognitive, emotional, and sensorimotor gating deficits. Wildtype (+/+), rl/rl, and hybrid (+/rl) mice were tested in open field, light-dark, PPI, nose poke, and passive avoidance after receiving 1.0 mg/kg of risperidone or vehicle via oral gavage for 3 weeks, and dosing continued throughout testing. Overall, there were few significant effects of the drug, but when it did have an effect on the rl/rl, it worsened its performance, and so the results could not support the hypothesis. Future research should re-examine the rl/rl in a wider battery of behavioral tests in order to determine if the rl/rl models another disorder, such as autism."--Abstract from author supplied metadata.

Additional Information

Publication
Thesis
Language: English
Date: 2006
Keywords
reeler mutant mouse(rl/rl), behavioral model, schizophrenia, antipsychotic, risperidone
Subjects
Risperidone--Research
Schizophrenia--Research
Mice as laboratory animals