The Relation of Documented Coronary Artery Disease to Levels of Total Cholesterol and High-Density Lipoprotein Cholesterol
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- H. William Gruchow, Professor (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: Recommendations for identifying persons at high risk for coronary heart disease are based primarily on levels of total and low-density lipoprotein cholesterol. We examined whether, given knowledge of these levels, information on the high-density lipoprotein cholesterol level would improve the prediction of arteriographically documented coronary artery disease among 591 men. We found that even at levels of total and low-density lipoprotein cholesterol considered desirable, high-density lipoprotein cholesterol was inversely related to disease severity. For example, among the 112 men with a total cholesterol level <180 mg per dl, the mean occlusion score (representing the overall severity of disease) was 107 among men with a high-density lipoprotein cholesterol level =30 mg per dl vs a mean score of 52 among men with levels =45 mg per dl. Furthermore, men with low levels of both low-density lipoprotein cholesterol (<110 mg per dl) and high-density lipoprotein cholesterol (=30 mg per dl) had as much occlusive disease as did men with high levels of both lipoprotein fractions. Given information on the ratio of high-density lipoprotein cholesterol to total cholesterol, the actual levels of the lipoprotein fractions did not improve disease prediction. Our results emphasize the importance of considering high-density lipoprotein cholesterol when assessing coronary heart disease risk.
Keywords: cholesterol levels, HDL lipoproteins, LDL lipoproteins, coronary artery disease, lipids.
The Relation of Documented Coronary Artery Disease to Levels of Total Cholesterol and High-Density Lipoprotein Cholesterol
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Created on 1/1/1994
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Additional Information
- Publication
- Freedman DS, Croft JB, Anderson AJ, Byers T, Jacobsen SJ, Gruchow HW, Barboriak JJ. The relation of documented coronary artery disease to levels of total and high-density lipoprotein cholesterol. Journal of Epidemiology 5:80-87, 1994.
- Language: English
- Date: 1994
- Keywords
- Coronary artery disease, Cholesterol, Lipoprotein, cholesterol, Coronary heart disease