Weight regain and breast cancer-related biomarkers following an exercise intervention in postmenopausal women

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Jessica McNeil, Assistant Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/

Abstract: Background: Epidemiologic studies have reported associations between weight fluctuations and postmenopausal breast cancer risk, however, the biological markers involved in this association are unknown. This study aimed to explore the associations between breast cancer-related biomarkers and weight regain following exercise-induced weight loss. Methods: From the 400 participants included in the Breast Cancer and Exercise Trial in Alberta, a total of 214 lost weight during the intervention and had follow-up blood samples, body composition and covariate measurements. Outcomes were measured at baseline, 12-months (end of the study) and 24-months (follow-up). Results: During follow-up, weight regain was 1.80 kg (95% CI: -0.40, 3.90), and was significantly associated with increases in estradiol (treatment effect ratio (TER) = 1.03, 95% CI: 1.01, 1.04), estrone (TER = 1.02, 95% CI: 1.01, 1.03), free estradiol (TER = 1.04, 95% CI: 1.02, 1.05), the homeostatic model assessment for insulin resistance (TER = 1.03, 95% CI: 1.02, 1.05), insulin (TER = 1.03, 95% CI: 1.01, 1.04), and decreases in sex hormone binding globulin (SHBG) (TER= 0.98, 95% CI: 0.97, 0.99) levels. Non-statistically significant associations were found for glucose and CRP. Furthermore, a statistically significant linear trend of increasing levels for all biomarkers, and decreasing SHBG, across weight regain categories was found. Conclusions: These results suggest that weight regain following exercise-induced weight loss is associated with breast cancer-related biomarker changes. Impact: These findings provide evidence to support the importance of developing effective strategies to prevent weight regain and consequently, decrease postmenopausal breast cancer risk via changes in adiposity-related biomarkers.

Additional Information

Cancer Epidemiology, Biomarkers & Prevention
Language: English
Date: 2021
Body composition, breast cancer prevention, weight fluctuations, physical activity

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