Selenium-dependent glutathione peroxidase modules encoded by RNA viruses
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Ethan W Taylor, Senior Research Professor (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: Glutathione peroxidase (GPx) is the prototypical eukaryotic selenoprotein, with the rare amino acid selenocysteine (Sec) at the enzyme active site, encoded by the UGA codon in RNA. A DNA virus, Molluscum contagiosum, has now been shown to encode a functional selenium-dependent GPx enzyme. Using modifications of conventional sequence database searching techniques to locate potential viral GPx modules, combined with structurally guided comparative sequence analysis, we provide compelling evidence that Se-dependent GPx modules are encoded in a number of RNA viruses, including potentially serious human pathogens like HIV-1 and hepatitis C virus, coxsackievirus B3, HIV-2, and measles virus. Analysis of the sequences of multiple viral isolates reveals conservation of the putative GPx-related features, at least within viral subtypes or genotypes, supporting the hypothesis that these are functional GPx modules.
Selenium-dependent glutathione peroxidase modules encoded by RNA viruses
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Created on 10/20/2020
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Additional Information
- Publication
- Biological Trace Element Research 70, 97–116 (1999). https://doi.org/10.1007/BF02783852
- Language: English
- Date: 1999
- Keywords
- AIDS, genomic analysis, glutathione peroxidase, hepatitis C virus, HIV, measles virus, retrovirus, selenium, selenoproteins