Highly water-soluble, near-infrared emissive BODIPY polymeric dye bearing RGD peptide residues for cancer imaging
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Jianjun Wei, Associate Professor (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: Near-infrared emissive BODIPY polymeric dye bearing cancer-homing cyclic arginine–glycine–aspartic acid (RGD) peptide residues (polymer B) was prepared by post-polymerization functionalization of BODIPY polymeric dye bearing bromo groups through tetra(ethylene glycol) tethered spacers (polymer A) with thiol-functionalized RGD cancer-homing peptide through thioether bonds under a mild basic condition. Polymer B possesses excellent water solubility, good photostability, biocompatibility and resistance to nonspecific interactions to normal endothelial cells, and can efficiently detect breast tumor cells through specific cooperative binding of cancer-homing RGD peptides to avß3 integrins of cancer cells while its parent polymer A without RGD residues fails to target cancer cells.
Highly water-soluble, near-infrared emissive BODIPY polymeric dye bearing RGD peptide residues for cancer imaging
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Created on 6/3/2020
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Additional Information
- Publication
- Analytica Chimica Acta, 2013, 758, 138–144.
- Language: English
- Date: 2013
- Keywords
- BODIPY dye, Conjugated polymer, Cancer imaging, Fluorescence, RGD peptide