Calmodulin inhibitory activity of the malbrancheamides and various analogs
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Mario Figueroa Saldivar, Adjunct Faculty (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: The preparation and biological activity of various structural analogs of the malbrancheamides are disclosed. The impact of indole chlorination, C-12a relative stereochemistry, and bicyclo[2.2.2]diazaoctane core oxidation state on the ability of these analogs to inhibit calmodulin dependent phosphodiesterase (PDE1) was studied, and a number of potent compounds were identified.
Calmodulin inhibitory activity of the malbrancheamides and various analogs
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Additional Information
- Publication
- Bioorganic and Medicinal Chemistry Letters, 18 (24), pp. 6479-6481
- Language: English
- Date: 2008
- Keywords
- Calmodulin inhibition, Malbrancheamide, Prenylated indole alkaloid