Investigation of dietary zinc and linoleic acid interactions in the Sprague-Dawley rat

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Patrick Vincent McCarthy (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site:
Aden C. Magee

Abstract: Ihe purpose of this Study was to investigate the hypothesis of a dietary interaction in young rats fed diets with and without zinc and linoleic acid. The parameters used to assess the interaction(s) included feed intake; weight gain; leukocyte alkaline phosphatase; bleeding time; appearance/muscle tone; dermal lesions; plasma zinc; plasma fatty acid profile; the testicular mineral concentrations of zinc, copper, iron, and manganese, and the total number of circulating leukocytes, granulocytes, and platelets in the animals fed the experimental diets. A randomized block design, based on initial body weights, involving a 22 factorial treatment arrangement was used in this study. Factors included two levels of zinc (1.5 ppn and 40 :ppn) and two levels of linoleic acid (0% and 2% of total dietary calories). The experimental phase consisted of 4 test diets which were fed to 24 rats for 33 days. Data were analyzed using fixed effects repeated measures (RIANOVA), mltivariate (MANOVA), or univariate (ANOVA) analysis of variance models. When either RMANOVA or MANOVA was employed. Roy's Maximum Root Criterion was used to test the hypothesis that the diets had no overall effect on the observed results.

Additional Information

Language: English
Date: 1988
Rats $x Physiology
Zinc $x Physiological effect

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