Physiological and morphological effects of short and long term lid-suture on cells in the lateral geniculate nucleus of cats

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Martha Grace MacAvoy (Creator)
Institution
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/
Advisor
Walter L. Salinger

Abstract: This study addresses three main issues which have clearly arisen from the literature and when answered, bear directly on the role of experience on neural development. In order to address these issues, 22 cats were reared with varying durations of lid suture and LGNd cell encounter rates and cell body sizes were collected. Control data were collected from normal subjects. Subjects reared with lid suture and from which data were collected before 17 months of age showed a reduction in the electrophysiological encounter rate for Y-cells and a reduction in average cell body size in geniculate laminae innervated by the deprived eye. Subjects from which data were collected at or after 17 months of age did not show a reduction in Y-cell encounter rate. In fact, it appears that X-cells were suppressed in the older subjects. Average cell body sizes in deprived geniculate laminae on the other hand, were smaller than normal. In these older subjects however, the relative difference between soma sizes in deprived and nondeprived laminae appears to decrease.

Additional Information

Publication
Dissertation
Language: English
Date: 1986
Subjects
Developmental neurobiology $x Research
Vision $x Research
Eye $x Research

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