An Electronic Analog of Synthetic Genetic Networks

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Edward Hellen (Creator)
Institution
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/

Abstract: An electronic analog of a synthetic genetic network known as the repressilator is proposed. The repressilator is a synthetic biological clock consisting of a cyclic inhibitory network of three negative regulatory genes which produces oscillations in the expressed protein concentrations. Compared to previous circuit analogs of the repressilator, the circuit here takes into account more accurately the kinetics of gene expression, inhibition, and protein degradation. A good agreement between circuit measurements and numerical prediction is observed. The circuit allows for easy control of the kinetic parameters thereby aiding investigations of large varieties of potential dynamics.

Additional Information

Publication
PLoS ONE 6(8): e23286
Language: English
Date: 2011
Keywords
Circuit models, Electronic circuits, Gene Regulation, Messenger RNA, Synthetic gene networks, Synthetic gene oscillators, repressilator

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