|Cellular Iron Depletion Weakens Induction of Heme Oxygenase-1 by Cadmium
||Heme oxygenase-1 is an inducible cytoprotective gene, although its induction by environmental factors is not completely understood. This study aimed to ascertain if specific nutritive factors or related compounds influence heme oxygenase-1 expression...
|Curcumin-induced GADD153 gene up-regulation in human colon cancer cells
||Ingestion of plant products containing the phenolic phytochemical, curcumin, has been linked to lower incidences of colon cancer, suggesting that curcumin has cancer chemopreventive effects. Supporting this suggestion at the cellular level, apoptosis...
|Curcumin-Induced GADD153 Upregulation: Modulation by Glutathione
||As we reported previously, GADD153 is upregulated in colon cancer cells exposed to curcumin. In the present study, we ascertained the involvement of glutathione and certain sulfhydryl enzymes associated with signal transduction in mediating the effec...
|Deoxycholate induces DNA damage and apoptosis in human colon epithelial cells expressing either mutant or wild-type p53
||Diets rich in fat result in higher concentrations of secondary bile acids or their salts in the colon, which may adversely affect cells of the colonic epithelium. Because secondary bile acids are thought to be genotoxic, exposing colon epithelial cel...
|Different Effects of Genistein on Molecular Markers Related to Apoptosis in Two Phenotypically Dissimilar Breast Cancer Cell Lines
||The association between consumption of genistein-containing soybean products and lower risk of breast cancer suggests a cancer chemopreventive role for genistein. Consistent with this suggestion, exposing cultured human breast cancer cells to geniste...
|Disparate effects of similar phenolic phytochemicals as inhibitors of oxidative damage to cellular DNA
||Phenolic phytochemicals are natural plant substances whose cellular effects have not been completely determined. Nordihydroguaiaretic acid (NDGA) and curcumin are two phenolic phytochemicals with similar molecular structures, suggesting that they pos...
|Disruption of mitochondria during tocotrienol-induced apoptosis in MDA-MB-231 human breast cancer cells
||Tocotrienols, which are Vitamin E isoforms, are known to inhibit the growth of human breast cancer cells due partly to apoptosis. However, the characterization of tocotrienol-induced apoptosis is incomplete, particularly what happens during the initi...
|Effect of copper deficiency on oxidative DNA damage in Jurkat T-lymphocytes
||The micronutrient copper is a catalytic cofactor for copper, zinc superoxide dismutase and ceruloplasmin, which are two important antioxidant enzymes. As such, a lack of copper may promote oxidative stress and damage. The purpose of this study was to...
|Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA
||Phenolic phytochemicals are thought to promote optimal health, partly via their antioxidant effects in protecting cellular components against free radicals. The aims of this study were to assess the free radical-scavenging activities of several commo...
|Epigallocatechin Gallate Protects U937 Cells Against Nitric Oxide-induced Cell Cycle Arrest and Apoptosis
||Ingesting phenolic phytochemicals in many plant products may promote health, but the effects of
phenolic phytochemicals at the cellular level have not been fully examined. Thus, it was determined if the tea phenolic phytochemical, epigallocatechin g...
|Increased GADD Gene Expression in Human Colon Epithelial Cells Exposed to Deoxycholate
||The colonic epithelium is often exposed to high concentrations of secondary bile acids, which stresses the epithelial cells, leading potentially to activation of stress- response genes. To examine this possibility in vitro, the purpose of this study ...
|Increased GADD153 Gene Expression During Iron Chelation-Induced Apoptosis in Jurkat T-Lymphocytes.
||Depriving cells of iron likely stresses them and can result in cell death. To examine the potential relationship between this form of stress and cell death, Jurkat T-lymphocytes were made iron-deficient by exposing them to the iron chelator, deferoxa...
|Induction of GADD Gene Expression by Phenethylisothiocyanate in Human Colon Adenocarcinoma Cells
||Phenethylisothiocyanate (PEITC), a potential cancer chemopreventive agent, induces colon cancer cell death, but the mechanism is not entirely clear. Therefore, the aim of this study was to further clarify the molecular effects of PEITC in causing dea...
|Paradoxical Effect of Diphenyleneiodonium in Inducing DNA Damage and Apoptosis
||Diphenyleneiodonium (DPI) is often used as a molecular tool in unravelling redox-sensitive cellular events involving NADPH oxidase. However, to better understand unexpected actions of DPI, it was ascertained if DPI affects cellular DNA. DPI induced s...
|Protection of human colon epithelial cells against deoxycholate by rottlerin
||The bile salt, deoxycholate (DOC), can harm cells and cause disease. Hence, there is interest in identifying compounds capable of protecting cells against DOC. In HCT-116 colon epithelial cells, DOC increased generation of reactive oxygen species and...
|Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation (Review)
||Phytochemicals are potential cancer chemopreventive agents, based partly on cellular research establishing that phytochemicals inhibit the proliferation of cancer cells. To elucidate the mechanism of phytochemicals, a basic understanding is needed of...
|Upregulation of GADD153 by Butyrate: Involvement of MAPK
||Butyrate inhibits the proliferation of cancer cells, but the early molecular events initiated by butyrate have not been fully identified. Herein, butyrate is shown to affect the growth arrest and DNA damage–inducible gene 153 (GADD153) in HCT-116 hum...
|Upregulation of haeme oxygenase-1 by zinc in HCT-116 cells
||Haeme oxygenase-1 (HO-1) is often viewed as a cytoprotective gene. Toxic heavy metals induce HO-1, but it is unclear whether particular metal micronutrients also induce HO-1. Hence, the ability of exogenously-added copper, iron and zinc to influence ...