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Theses & Dissertations

Submissions

Reggio, Patricia

UNCG

There are 7 item/s.

TitleDateViewsBrief Description
The study of allosteric modulator sites at the cannabinoid CB1 receptor 2009 922 Org 27569, Org 27759 and Org 29647 are the first discovered allosteric modulators of the cannabinoid CB1 receptor. These ligands are thought to bind to "accessory binding sites" at the receptor . Binding of the Org allosteric modulators has been show...
Structural characterization and docking studies of acetylcholine binding proteins. 2009 655 Neuronal Nicotinic Receptors (NNRs) are ligand gated ion channels located both pre- and postsynaptically in the peripheral and central nervous systems. NNRs are important pharmaceutical targets for schizophrenia, pain, epilepsy, tobacco dependence, T...
In silico refinement of a computer model of GPR55, a cannabinoid receptor 2011 478 Cannabinoid receptors have great therapeutic potential and are important targets in drug discovery. As part of a broader project whose long-term goal is the determination of the basis for the actions of cannabinoids at the molecular level, this resea...
The study of allosteric modulator sites at the cannabinoid CB1 receptor 2009 922 Org 27569, Org 27759 and Org 29647 are the first discovered allosteric modulators of the cannabinoid CB1 receptor. These ligands are thought to bind to "accessory binding sites" at the receptor . Binding of the Org allosteric modulators has been show...
Building and refinement of an in silico homology model of a novel G protein-coupled receptor: GPR35 2011 902 Human GPR35 (hGPR35), a recently deorphanized Class A G-protein coupled receptor, has been shown to exhibit prominent expression in immune and gastrointestinal tissues, with additional expression in pancreatic islets, skeletal muscle, lung tissue, an...
Refinement of the conformation of selected transmembrane helices in the cannabinoid receptor GPR55 using conformational memories (CM). 2011 359 GPR55 is a newly de-orphanized cannabinoid receptor which belongs to the class A G-protein coupled receptors (GPCRs) family and binds constitutes of the plant, Cannabis sativa. It has been suggested that the manipulation of GPR55 may have a therapeut...
Computational study of RTI - 371, a positive allosteric modulator of the cannabinoid CB1 receptor 2011 715 It is now recognized that many G-protein-coupled receptors (GPCRs) contain allosteric binding sites for endogenous and/or synthetic ligands, which are topographically distinct from the agonist-binding site, which is known as the orthosteric site. In ...