|The Effect on Transcriptional Activity of Mutations that Alter Possible Phosphorylation Sites in Drosophila melanogaster Ultraspiracle (USP)
||During insect development, steroid hormones interact with two members of the nuclear receptor superfamily, ecdysone receptor (EcR) and Ultraspiracle (USP) to bring about cellular changes. To determine the functional properties of mutations of serine ...
|Functional analysis of a Drosophila/Chironomous ultraspiracle chimera to examine the role of USP in ecdysteroid-inducible gene expression.
||The molting hormone, 20-hydroxyecdysone (20E), orchestrates Drosophila development through the actions of the ecdysteroid receptor, which is a heterodimer of two members of the nuclear hormone receptor superfamily, EcR and Ultraspiracle (USP). The Ec...
|A thermodynamic model of RXR self-association and ligand binding
||This study looked at the thermodynamics of ligand binding to the Retinoid X Receptor (RXR) and the formation of the RXR auto-repressive tetramer. Often called the "Master Coordinator" RXR is a required partner for activation of class II nuclear recep...