|An analysis of the mechanism of Dictyostelium myosin II heavy chain kinase B in substrate targeting
||Previous studies have shown that myosin heavy chain kinase A and B (MHKA and MHKB) are able to phosphorylate and disassemble Dictyostelium discoideum myosin II bipolar filaments by directly targeting myosin II via a conserved region of WD repeats, al...
|Studies of the Actin Binding Activity of Dictyostelium discoideum Myosin II Heavy Chain Kinase A.
||Dictyostelium discoideum is a primitive, eukaryotic organism that relies on myosin II and actin contraction for cytokinesis, migration, and other important cellular processes. In order for contraction to occur, myosin II monomers must first assemble ...
|Cloning & Cellular Characterization of Myosin II Heavy Chain Kinase D from Dictyostelium discoideum.
||The thesis research presented here focused on studies of a novel myosin II heavy chain kinase D (MHCK D) expressed in Dictyostelium discoideum cells. MHCK D is made up of four distinct domains: a short coiled-coil region (Coil), a region rich in seri...
|Localization of Myosin II and identification of its potential upstream regulators in Dictyostelium discoideum
||The thesis work presented here aimed to understand how myosin II is regulated in Dictyostelium discoideum within the context of chemotactic signaling and cell migration. Myosin II filaments are regulated via phosphorylation of the heavy chain tails, ...
|Studies of Alpha Kinase 1 and its potential to influence cytoskeletal reorganization
||Maintaining and remodeling the actin cytoskeleton is a critical part of normal cellular functioning for all eukaryotes, as it is crucial for cell movement, endocytosis, exocytosis, and maintaining cellular morphology. Within the social amoeba Dictyos...