Chiu, Norman

uncg

There are 13 item/s.

TitleDateViewsBrief Description
Quantitative Measurements of Carcinogen-DNA Adduct Using MALDI Time-Of-Flight Mass Spectrometry 2008 1705 Many carcinogens and their electrophilic metabolites react readily with DNA, and form different types of DNA adducts. Clinically, DNA adducts have been linked to cancer diseases. Also, different DNA adducts have been used as biomarkers to monitor the...
Detection and sequencing of microRNA using MALDI time-of-flight mass spectrometry 2010 3629 The discovery of microRNAs (miRNAs) and their abilities to regulate in vivo protein synthesis have led to growing interests in miRNA research. Due to their functions on regulating cellular processes that are related to diseases such as cancer, miRNAs...
Mass spectrometric methods and bioinformatics tools for accurate identification of MicroRNA biomarkers 2012 1500 MicroRNA (miRNA) are a class of endogenous non-protein-coding RNA of ~19-25 nucleotides long that post-transcriptionally regulate protein expression by targeting messenger RNAs for cleavage or translational repression. MiRNAs have been implicated in ...
Investigating the role of plasma proteins in the cellular uptake of metallic nanoparticles 2013 1047 In recent years applications of nanotechnology have increased at an unprecedented rate. Nanotechnology, which is defined as the engineering of matter on an atomic and molecular scale, has proven beneficial in a number of scientific fields. In particu...
Whole cell mass spectroscopy as a cytotoxicity screening method 2013 751 Whole cell mass spectroscopy (WCMS) is a method that has gain popularity in the last decade. WCMS saves time by omitting extensive sample preparation for the mass spectral analysis of microorganisms. WCMS has been mainly used for profiling and identi...
Cytotoxicity Screening Matrix Assisted Laser Desorption Ionization Mass Spectrometery for nanoparticle biomarker detection 2014 688 Toxicology is a broad topic that aims to assess the risk of chemicals on living organisms. It has been acknowledged that everything is toxic to a living organism. What distinguishes a toxin from a remedy depends on the dose 1. Presently, there are to...
Detection of Argonaute (Ago) protein associated MiRNA by combining anti-ago antibody recognition with real-time PCR 2014 1050 MicroRNAs (miRNAs) are small molecules of noncoding RNA that range between ~19-22 nucleotides in length. In recent years, scientists have observed that these small RNA molecules exist in the extracellular environment within eukaryotic organisms. Furt...
Evaluation of analytical tools for studying the host and gut microbe relationships in Type 2 Diabetes 2016 421 Type 2 Diabetes (T2D) is becoming one of the most prevalent diseases in the world. With this comes an increased burden in healthcare and a lower quality of life for those affected by diabetes. Further, certain populations are more susceptible to T2D ...
Method development for studying bacterial messenger RNA as biomarkers 2017 330 The gut microbiome is a collection of microbes that exist in the digestive tract, which includes bacteria, viruses and archaea. These microbes are symbiotic to their host and are essential to the proper development and ongoing health of digestive and...
Detecting the cellular response of Lactobacillus reuteri with nanospray desorption electrospray ionization mass spectrometry 2017 276 Mass spectrometry has proven to be a useful tool in microbiology research, especially for rapid identification of bacterial strains based on their unique mass spectral pattern. Traditionally, matrix-assisted laser desorption/ionization (MALDI) mass s...
Computational modeling of small non-coding RNA intramolecular structures and the determination of their collisional cross sections 2018 141 Ribonucleic acid (RNA) plays important and fundamental roles in different biological activities which include transmission of genetic information, regulation of gene expression, catalysis for biochemical reactions and biomarkers for different disease...
Ion mobility mass spectrometry of isomeric RNA biomarkers 2018 282 Ion mobility spectrometry is an analytical technique that separates gaseous ions depending on their mobility in a gas filled cell under the influence of an electric field. More compact ions transit through the cell more easily than elongated ions of ...
Mass spectrometric detection of cortisol in hair samples 2018 66 Stress is experienced all over the world in various forms. It is typically diagnosed through the evaluation of psychological and physical factors. These diagnoses are often time consuming. Stress can negatively impact individual’s health and quality ...