|Impact of trans-10, cis-12 conjugated linoleic acid on interleukin (IL)-6 and IL-8 and adipogenic genes in cultures of human adipose tissue explants
|| "Obesity has reached epidemic proportions in the United States, currently ranking second among causes of preventable deaths. Our research group has shown in cultures of differentiated human adipocytes that 30 uM trans-10, cis-12 Conjugated Linoleic ...
|The antiobesity mechanism of conjugated linoleic acid
||Given the steady rise in obesity worldwide, it is important to identify dietary compounds that prevent adiposity. One dietary strategy is supplementation with conjugated linoleic acid (CLA), which has been demonstrated to reduce body fat mass. Howeve...
|Grape powder extract (GPE) attenuates markers of inflammation in human macrophages.
||Obesity is linked to chronic inflammation in white adipose tissue (WAT) which is exacerbated by infiltrating macrophages (MΦ)s. Grape powder extract (GPE) contains polyphenols that have the potential to prevent this inflammatory response that c...
|Conjugated linoleic acid (CLA) promotes inflammation to a greater extent in human adipocytes compared to preadipocytes
||Due to the increasing prevalence of obesity and diabetes among children and adults worldwide, it is imperative to identify dietary strategies that promote weight control. One potential anti-obesity compound is conjugated linoleic acid (CLA), sold wor...
|Grape polyphenols attenuate inflammation and insulin resistance in human adipocytes and obese mice
||Obesity is rapidly increasing worldwide among all age groups. Insulin resistance or type 2 diabetes is one of several debilitating health problems associated with obesity. An emerging feature of obesity and type 2 diabetes is their linkage with chron...
|Impact of California table grapes on systemic inflammation, insulin resistance, and hepatic steatosis in mice fed an American-type diet
||The incidence of obesity is increasing worldwide, currently affecting over 400 million people. With obesity, expansion of white adipose tissue (WAT) contributes to a chronic, low-grade inflammatory response that is associated with the formation of co...
|Anti-obesity mechanisms of conjugated linoleic acid (CLA): role of inflammatory signaling and browning in white adipose tissue
||Overweight and obesity are the most widespread nutritional diseases in the U.S., which greatly increase chronic disease risks and mortality. Therefore, it is urgent to develop a relatively efficacious and safe strategy for the weight management. Cons...