|A novel method for the selective elimination of HIV infected cells: dexamethasone and procaine as a combination therapy prototype
||It has been established that various combinations of three or more antiretroviral drugs will lead to durable inhibition of HIV replication in patients. Despite its success in controlling the infection, highly active antiretroviral therapy (HAART) doe...
|Cloning and in vitro characterization of a novel ribosomal frameshifting site in the HIV-1 gag gene
||Most retroviruses and various other organisms have a capability of producing multiple protein products from a single RNA species using overlapping genes and taking advantage of ribosomal frameshifting (Jacks T. , 1990; Taylor, 1994). This phenomenon ...
|Mechanistic studies of water soluble fullerenes as free radical scavengers, biological antioxidants and NF-kappaB inhibitors
||Since their discovery, fullerenes and fullerene derivatives have been the subject of intense research because of their unique properties and potential applications. The combination of a network of conjugated double bonds with high electron affinity m...
|Elucidation of the cellular genes, pathways, and biochemical mechanisms involved in HIV stimulation by aqueous tobacco smoke extract.
||HIV infection, and tobacco smoking, two areas of major health concern which continue to grow worldwide, both of which have detrimental health effects on the population. The point of intersection where these two health concerns cross is the focus of t...
|Targeting the Atypical Chemokine Receptor ACKR3/CXCR7 for the treatment of cancer and other diseases
||One of the greatest challenges in fighting cancer is cell targeting and biomarker selection. The Atypical Chemokine Receptor ACKR3/CXCR7 is expressed on many cancer cell types, including breast cancer and glioblastoma, and binds the endogenous ligand...
|Nutritional manipulation of HIV/AIDS: the effects of ergothioneine and cultural complementary and alternative medicines on HIV
||The use of complementary and alternative medicine in minority populations in individuals infected with HIV is prevalent and these cultural practices require laboratory confirmation to determine effectiveness. The manipulation of HIV via nutritional s...
|Ionic modulation of QPX stability as a nano - switch regulating gene expression in neurons
||G-quadruplexes (G-QPX) have been the subject of intense research due to their unique structural configuration and potential applications, particularly their functionality in biological process as a novel type of nano–switch. They have been found in c...