| Title | Date | Views | Brief Description |
|---|
| A novel method for the selective elimination of HIV infected cells: dexamethasone and procaine as a combination therapy prototype |
2011 |
20034 |
It has been established that various combinations of three or more antiretroviral drugs will lead to durable inhibition of HIV replication in patients. Despite its success in controlling the infection, highly active antiretroviral therapy (HAART) doe... |
| Co-translational genetic switching during protein synthesis: the HIV-1 Nef gene as a paradigm |
2016 |
715 |
The old maxim of “one gene, one mRNA, one protein” no longer holds, especially with viral genes. It is possible for one mRNA to encode several proteins of unrelated functions in overlapping reading frames of a single oligonucleotide, or for an additi... |
| Ultra-sensitive and multiplex detection of clinical biomarkers using a SPRi-based sensor |
2016 |
469 |
Reliable and reproducible biomarker analysis is the main focus of current clinical diagnostic approaches being developed for the sensitive detection and quantification of biomarkers in bodily fluids. Currently used tools are being revised for better ... |
| Ionic modulation of QPX stability as a nano - switch regulating gene expression in neurons |
2016 |
969 |
G-quadruplexes (G-QPX) have been the subject of intense research due to their unique structural configuration and potential applications, particularly their functionality in biological process as a novel type of nano–switch. They have been found in c... |
| Mechanistic studies of water soluble fullerenes as free radical scavengers, biological antioxidants and NF-kappaB inhibitors |
2014 |
2423 |
Since their discovery, fullerenes and fullerene derivatives have been the subject of intense research because of their unique properties and potential applications. The combination of a network of conjugated double bonds with high electron affinity m... |
| Elucidation of the cellular genes, pathways, and biochemical mechanisms involved in HIV stimulation by aqueous tobacco smoke extract. |
2014 |
1817 |
HIV infection, and tobacco smoking, two areas of major health concern which continue to grow worldwide, both of which have detrimental health effects on the population. The point of intersection where these two health concerns cross is the focus of t... |
| Genetic switching during protein synthesis and the role of quadruplexes in HIV-1’s nef gene |
2018 |
556 |
HIV-1 is still a prominent global public health issue responsible for the deaths of over 1 million people annually. It is a very complex virus that has been extensively studied over the past decade. The virus has adapted several mechanisms to maintai... |
| Cloning and in vitro characterization of a novel ribosomal frameshifting site in the HIV-1 gag gene |
2011 |
1880 |
Most retroviruses and various other organisms have a capability of producing multiple protein products from a single RNA species using overlapping genes and taking advantage of ribosomal frameshifting (Jacks T. , 1990; Taylor, 1994). This phenomenon ... |
| Targeting the Atypical Chemokine Receptor ACKR3/CXCR7 for the treatment of cancer and other diseases |
2015 |
2276 |
One of the greatest challenges in fighting cancer is cell targeting and biomarker selection. The Atypical Chemokine Receptor ACKR3/CXCR7 is expressed on many cancer cell types, including breast cancer and glioblastoma, and binds the endogenous ligand... |
| Nutritional manipulation of HIV/AIDS: the effects of ergothioneine and cultural complementary and alternative medicines on HIV |
2015 |
1089 |
The use of complementary and alternative medicine in minority populations in individuals infected with HIV is prevalent and these cultural practices require laboratory confirmation to determine effectiveness. The manipulation of HIV via nutritional s... |
| Differential effect of alkali metal ions on the structure and stability of DNA G-Quadruplexes with potential role in the regulation of gene expression |
2018 |
1093 |
G-quadruplexes (G-QPX) have been the subject of great interest in research due to their exclusive structural configuration, functionality and potential roles in biological applications particularly gene regulation and Nano-switch applications. Initia... |
| Measuring distances between nucleotides using CW- EPR and dual site-directed spin labels to distinguish parallel quadruplexes from B-DNA |
2018 |
415 |
The proper identification of DNA secondary structure is paramount for determining possible factors that can influence rates of genomic transcription. Structures such as DNA quadruplexes (QPX), which are found in guanine-rich regions of DNA, can have ... |
| RNA viruses : the strategies they employ to interfere with host cell protein expression and to synthesize viral proteins, and a new way to identify their RNA in biological samples |
2021 |
227 |
This dissertation is composed of the projects I worked on that were able to be made into scientific papers. My projects centered primarily around viral RNAs and how they interact with host cell mRNAs coding for selenoprotein, and if these effects wer... |
| Identification of SARS-CoV-2 main protease cleavage sites in host cellular selenoproteins and glutathione-related proteins |
2022 |
241 |
SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) continues to be a global threat. Even as vaccines and therapeutics become increasingly available, COVID-19 (Coronavirus Disease-2019) infections continue to rise, leading to the proliferati... |
| Disruption of host selenobiology by SARS-CoV-2 and Ebola virus via RNA:RNA antisense interactions |
2023 |
134 |
Selenium is an essential, but often overlooked, element in maintaining the health of our biological systems. Occupying the redox center of different selenoproteins, such as thioredoxin reductase (TXNRD) or glutathione peroxidase as selenocysteine (Se... |
| Studies of the human CCR3 chemokine receptor: development of a cell line stably expressing CCR3, receptor purification and characterization, and phosphopeptide enrichment methods to study the CCR3 GPCR signaling pathway |
2016 |
1298 |
Studies of the human CCR3 chemokine receptor: development of a cell line stably expressing CCR3, receptor purification and characterization by mass spectrometry, and phosphoproteomic methods to study the CCR3 GPCR signaling pathway. Chemokine Recepto... |