Kepley, Christopher

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Fullerenes and their potential in nanomedicine 2015 1457 Carboxyfullerenes are closed carbon spheres which are being actively pursued globally for a wide range of applications. Their inherent properties and ability to be functionalized with side-chains results in nearly limitless new chemical structures ma...
Studies examining the infectivity of Human Immunodeficiency Virus (HIV) on human immune cells 2017 8 Human immunodeficiency virus (HIV) establishes a latent infection in cells to ensure a persistent infection throughout an infected individual’s life. HIV can establish this latent infection in a variety of cells. Highly Active Anti-Retroviral Treatme...
Studies examining the anti-aging effects of fullerenes 2017 6 Research on aging has been invigorated by recent findings suggesting certain mutations in various invertebrate models (yeast, worms, and flies) can slow down aging and improve healthspan. Reactive Oxygen Species (ROS) production and manipulation of t...
Differentiation of functional human mast cells from adipose derived stem cells and their application in allergo-oncology and the treatment of breast cancer 2018 188 Mast Cells are important yet poorly understood components of the immune system. Study of mast cells has been hampered by difficulty in obtaining primary cells, the lack of functional cell lines and the high degree of dissimilarity between human and m...
Studies examining mast cells, nanomaterials, and immunoglobulins to treat breast cancer, atherosclerosis, and allergies 2019 43 Mast cells (MC) are important immune sentinels found in most tissue and widely recognized for their role as mediators of Type I hypersensitivity. However, they also secrete anti-cancer mediators such as tumor necrosis factor alpha (TNF-a) and granulo...