Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the Herpotrichiellaceae
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Nicholas Oberlies, Patricia A. Sullivan Distinguished Professor of Chemistry (Creator)
- Huzefa A. Raja, Research Scientist (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: As part of ongoing efforts to isolate biologically active fungal metabolites, a cyclic pentapeptide, sheptide A (1), was discovered from strain MSX53339 (Herpotrichiellaceae). The structure and sequence of 1 were determined primarily by analysis of 2D NMR and HRMS/MS data, while the absolute configuration was assigned using a modified version of Marfey’s method. In an in vitro assay for antimalarial potency, 1 displayed a pEC50 value of 5.75?±?0.49 against malaria-causing Plasmodium falciparum. Compound 1 was also tested in a counter screen for general cytotoxicity against human hepatocellular carcinoma (HepG2), yielding a pCC50 value of 5.01?±?0.45 and indicating a selectivity factor of ~6. This makes 1 the third known cyclic pentapeptide biosynthesized by fungi with antimalarial activity.
Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the Herpotrichiellaceae
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Created on 4/10/2024
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Additional Information
- Publication
- Shepherd, R.A., Earp, C.E., Cank, K.B., Raja, H.A., Burdette, J., Maher, S.P., Marin, A.A., Ruberto, A.A., Mai, S.L., Darveaux, B.A., Kyle, D.E. 2023. Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the Herpotrichiellaceae. The Journal of Antibiotics 76: 642–649.
- Language: English
- Date: 2023
- Keywords
- sheptide, cyclic pentapeptide, Herpotrichiellaceae, fungal strain